吳永昌 教授

 
專長:
  1. 天然藥物學
  2. 中草藥新藥研發
 
現職:
  • 中國醫藥大學副校長
  • 中國醫藥大學中醫學系講座教授
 
學歷:
  • 高雄醫學大學醫學研究所(基礎醫學)博士
  • 高雄醫學大學醫學研究所(基礎醫學)碩士
  • 高雄醫學大學藥學系學士
 
電話: 04-22057153
傳真: 04-22060428
電子信箱: yachwu@mail.cmu.edu.tw
 
簡介:
    吳永昌教授現為中國醫藥大學講座教授兼副校長,曾擔任高雄醫學大學天然藥物研究所所長、研發長與講座教授、國科會「藥學及中醫藥學門」召集人、經濟部技審會與行政院中醫藥委員會委員,曾獲得「國科會傑出研究獎」、「王民寧醫藥研究傑出貢獻獎」與「李天德卓越醫藥科技獎」等多項榮譽。吳教授迄今發表SCI國際期刊論文380篇,多數為該領域排名前百分之十之期刊,文章被引用次數高達2000餘次。2009年由中藥材阿魏研發抗H1N1之研究成果發表在Journal of Natural Products,被遴選為breaking news。吳教授在學術上最大的貢獻係將台灣本土特有種藥用植物,作系列成分化學結構解析,近幾年更從事抗癌分子生物學及訊息傳遞的基礎研究以提昇藥物之研發及癌症治療可行性,為由基礎至臨床應用之轉譯醫學傑出研究學者。
 
代表性著作:
  1. Zeng YF, Wa JQ, Shi LY, Wang K, Zhou B, Tang Y, Zhang DY*, Wu YC, Hua WY, and Wu XM. Synthesis and evaluation of cytotoxic effects of novel α-methylenelactone tetracyclic diterpenoids. Bioorg Med Chem Lett. 2012,22:1922-5.
  2. Chao CH, Chou KJ, Huang CY, Wen ZH, Hsu CH, Wu YC, Dai CF, and Sheu JH*. Steroids from the Soft Coral Sinularia crassa. Mar Drugs 2012,10:439-50.
  3. Lan YH*, Peng YT, Thang TD, Hwang TL, Dai DN, Leu YL, Lai WC, and Wu YC*. New Flavan and Benzil Isolated from Fissistigma latifolium. Chem. Pharm. Bull. 2012,60:280-2.
  4. Hsu CC, Wu YC, Farh L, Du YC, Tseng WK, Wu CC, and Chang FR*. Physalin B from Physalis angulata triggers the NOXA-related apoptosis pathway of human melanoma A375 cells. Food and Chemical Toxicology 2012,50:619-24.
  5. Chung YM, Chang FR, Tseng TF, Hwang TL, Chen LC, Wu SF, Lee CL, Lin ZY, Chuang LY, Su JH*, and Wu YC*. A novel alkaloid, aristopyridinone A and anti-inflammatory phenanthrenes isolated from Aristolochia manshuriensis. Bioorg. Med. Chem. Lett.2011, In press.
  6. Chen HM, Chang FR, Hsieh YC, Cheng YJ, Hsieh KC, Tsai LM, Lin AS, Wu YC*, and Yuan SS*. A novel synthetic protoapigenone analogue, WYC02-9, induces DNA damage and apoptosis in DU145 prostate cancer cells through generation of reactive oxygen species. Free Radic. Bio. Med.2011, In press.
  7. Chen WY, Hsieh YA, Tsai CI, Kang YF, Chang FR, Wu YC*, and Wu CC*. Protoapigenone, a natural derivative of apigeninm, induces mitogen-activated protein kinase-dependent apoptosis in human breast cancer cells associated with induction of oxidative stress and inhibition of glutathione S-transferasep. Invest New Drugs 2011, In press.
  8. Lee CC, Lin YH, Chang WH, Lin PC, Wu YC*, and Chang JG. Squamocin modulates histone H3 phosphorylation levels and induces G1 phase arrest and apoptosis in cancer cells. BMC Cancer 2011,11:58.
  9. Lee JC*, Chen WC, Wu SF, Tseng CK, Chiou CY, Chang FR, Hsu SH, and Wu YC*. Anti-hepatitis C virus activity of Acacia confuse extract via suppressing cyclooxygenase-2. Antiviral Res. 2011,89:35-42.
  10. Lee CL, Huang CH, Wang HC, Chuang DW, Wu MJ, Wang SY, Hwang TL, Wu CC, Chen YL, Chang FR*, and Wu YC*. First total synthesis of antrocamphin A and its analogs as anti-inflammatory and anti-platelet aggregation agents. Org. Biomol. Chem. 2011,9 (1), 70-3.
  11. Lee CL, Liao YC, Hwang TL, Wu CC, Chang FR*, and Wu YC*. Ixorapeptide I and ixorapeptide II, bioactive peptides isolated from Ixora coccinea. Bioorg. Med. Chem. Lett. 2010,20:7354-7.
  12. Shih YT, Chen PS, Wu CH, Tseng YT, Wu YC*, and Lo YC*. Arecoline, a major alkaloid of the areca nut, causes neurotoxicity through enhancement of oxidative stress and suppression of the antioxidant protectivesystem. Free Radic. Bio. Med. 2010,49:1471-9.
  13. Liaw CC, Wu TY, Chang FR, and Wu YC*. Historic Perspectives on Annonaceous Acetogenins from the Chemical Bench to Preclinical Trials. Planta Med. 2010,76(13), 1390-404.
  14. Chang CL, Zhang LJ, Chen RY, Kuo LM, Huang JP, Huang HC, Lee KH, Wu YC* and Kuo YH*. Antioxidant and anti-inflammatory phenylpropanoid derivatives from Calamus quiquesetinervius. J. Nat. Prod. 2010,73(9):1482-8.
  15. Yen CY, Chiu CC, Chang FR, Chen JYF, Hwang CC, Hseu YC, Yang HL, Lee AYL, Tsai MT, Guo ZL, Cheng YS, Liu YC, Lan YH, Chang YC, Ko YC, Chang HW*, and Wu YC*. 4beta-Hydroxywithanolide E from Physalis peruviana (golden berry) inhibits growth of human lung cancer cells through DNA damage, apoptosis and G2/M arrest. BMC Cancer 2010,10:46 (8 pages)
  16. Yen CT, Wu CC, Lee JC, Chen SL, Morris-Natschke SL, Hsieh PW*, and Wu YC*. Cytotoxic N-(fluorenyl-9-methoxycarbonyl) (Fmoc)-dipeptides: Structure-activity relationships and synergistic studies. Eur. J. Med. Chem. 2010,45:2494-502.
  17. Yang PY, Chen MF, Tsai CH, Hu DN, Chang FR, and Wu YC*. Involvement of caspase and MAPK activities in norcantharidin-inducedcolorectal cancer cell apoptosis. Toxicology in Vitro 2010,24:766-75.
  18. Chang CL, Wang GJ, Zhang LJ, Tsai WJ, Chen RY, Wu YC*, and Kuo YH*. Cardiovascular protective flavonolignans and flavonoids from Calamus quiquesetinervius. Phytochemistry 2010,71:271-9.
  19. \
  20. Lee CL, Chiang LC, Cheng LH, Liaw CC, Abd El-Razek MH, Chang FR*, and Wu YC*. Anti-influenza A Viral (H1N1) and Cytotoxic Agents from Ferula assafoetida. J. Nat. Prod. 2009, 72:1568-72.
  21. Lan YH, Chang FR*, Pan MJ, Wu CC, Wu SJ, Chen SL, Wang SS, Wu MJ, and Wu YC*. New Cytotoxic Withanolides from Physalis peruviana. Food Chemistry 2009,116:462-9.
  22. Du YC, Lin AS, Wu CC, Hsieh PW, Chen YH, Chen IH, Chen SL, Yen HF, Lübken T, Chang FR*, and Wu YC*. New Cytotoxic Lupane Triterpenes from Perrottetia arisanensis. Planta Med.2009,75:848-55.
  23. Chen IH, Lu MC, Du YC, Yen MH, Wu CC, Chen YH, Hung CS, Chen SL, Chang FR* and Wu YC*. Cytotoxic Triterpenoids from the Stems of Microtropis japonica. J. Nat. Prod.2009,72:1231-6.
  24. Lin AS, Lin CR, Du YC, Lübken T, Chiang MY, Chen IH, Wu CC, Hwang TL, Chen SL, Yen MH, Chang FR*, and Wu YC*. Acasiane A and B and Farnesirane A and B, Diterpene Derivatives from the Roots of Acacia farnesiana. Planta Med.2009,75:256-61.
  25. Yen CT, Hwang TL, Wu YC*, and Hsieh PW*. Design and synthesis of new N-(fluorenyl-9-methoxycarbonyl) (Fmoc)-dipeptides as anti-inflammatory agents. Eur. J. Med. Chem. 2009,44:1933-40.
  26. Lee CL, Chang FR, Yen MH, Yu D, Liu YN, Bastow KF, Morris-Natschke SL, Wu YC* and Lee KH*. Cytotoxic phenanthrenequinones and 9,10-dihydrophenanthrenes from Calanthe arisanensis. J. Nat. Prod. 2009,72:210-3.
  27. Lu MC, Hwang SL, Chang FR, Chen YH, Hung CS, Wang CL, Chu YH, Pan SJ, and Wu YC*. Immunostimulatory effect of Antrodia cinnamomea extract on functional maturation of dendritic cells. Food Chemistry 2009,113:1049-57.
  28. Hsu HF, Houng JY*, Kuo CF, Tsaod N, and Wu YC*. Glossogin, a novel phenylpropanoid from Glossogyne tenuifolia, induced apoptosis in A549 lung cancer cells. Food Chem Toxicol.2008,46:3785-91.
  29. Chuang PH, Hsieh PW, Yang YL, Hua KF, Chang FR, Shiea J, Wu SH, and Wu YC*. Cyclopeptides with anti-inflammatory activities from the seeds of Annona montana. J. Nat. Prod. 2008,71:1365-70.
  30. Chen IH, Du YC, Lu MC, Hsieh PW, Wu CC, Chen SL, Yen HF, Chang FR*, and Wu YC*. New Lupane-type Triterpenoids from Microtropis fokienensis and Perrottetia arisanensis and Apoptotic Effect of 28-hydroxy-3-oxo-lup-20(29)-en-30-al. J. Nat. Prod. 2008,71:1352-7.
  31. Chen YL, Lan YH, Hsieh PW, Wu CC, Chen SL, Yen CT, Chang FR*, Hung WC, and Wu YC*. Bioactive Cembrane Diterpenoids of Anisomeles indica. J. Nat. Prod. 2008,71:1207-12.
  32. Chang HL, Su JH, Yeh YT, Lee YC, Chen HM, Wu YC*, and Yuan SSF*. Protoapigenone, a novel flavonoid, inhibits ovarian cancer cell growth in vitro and in vivo. Cancer Lett. 2008,267:85-95.
  33. Chen WY, Chang FR, Huang ZY, Chen JH, Wu YC*, and Wu CC*. Tubocapsenolide A, A Novel Withanolide, Inhibits Proliferation and Induces Apoptosis in MDA-MB-231 cells by Thiol Oxidation of Heat Shock Proteins. J. Biol. Chem. 2008,283:17184-93.
  34. Liaw CC, Yang YL, Chen M, Chang FR*, Chen SL, and Wu YC*. Mono-Tetrahydrofuran Annonaceous Acetogenins from Annona squamosa as Cytotoxic Agents and Calcium Ion Chelators. J. Nat. Prod. 2008,71:764-71.
  35. Yang YL, Hua KF, Chuang PH, Wu SH, Wu KY, Chang FR, and Wu YC*. New cyclic peptides from the seeds of Annona squamosa L. and their anti-inflammatory activities. J. Agric. Food Chem. 2008,56:386-92.
  36. Lee CL, Chang FR, Hsieh PW, Chiang MY, Wu CC, Huang ZY, Lan YH, Chen M, Lee KH, Yen HF, Hung WC, Wu YC*. Cytotoxic ent-abietane diterpenes from Gelonium aequoreum. Phytochemistry 2008,69:276-87.
  37. Yang YL, Chang SM, Wu CC, Hsieh PW, Chen SL, Chang FR*, Hung WC, Issa HH, and Wu YC*. Cytotoxic Sesquiterpene Lactones from Pseudoelephantopus spicatus. J. Nat. Prod. 2007,70:1761-5.
  38. Wang WY, Hsieh PW, Wu YC*, Wu CC*. Synthesis and pharmacological evaluation of novel _-nitrostyrene derivatives as tyrosine kinase inhibitors with potent antiplatelet activity. Biochemical Pharmacology. 2007,74:601-11.
  39. Lin AS, Nakagawa-Goto K, Chang FR, Yu D, Morris-Natschke SL, Wu CC, Chen SL, Wu YC*, and Lee KH*. First Total Synthesis of Protoapigenone and its Analogs as Potent Cytotoxic Agents. J. Med. Chem. 2007,50:3921-7.
  40. Chang HC*, Chang FR, Wu YC, Pan MR, Hung WC, and Wu YC*. A Bioactive Withanolide Tubocapsanolide A inhibits proliferation of human lung cancer cells via repressing Skp2 expression.” Mol. Cancer Ther. 2007,6:1572-8.
  41. Hsieh PW, Huang ZY, Chen JH, Chang FR*, Wu CC, Yang YL, Chiang MY, Yen MH, Chen SL, Yen HF, Lübken T, Hung WC, and Wu YC*. Cytotoxic Withanolides from Tubocapsicum anomalum. J. Nat. Prod. 2007,70:747-53.
  42. Lin AS, Chang FR, Yen HF, Björkeborn HMa, Norlen P, and Wu YC*. Novel Flavonoids of Thelypteris torresiana. Chem. Pharm. Bull. 2007,55(4):635-7.
  43. Hsieh PW, Hwang TL, Wu CC, Chiang SZ, Wu CI, and Wu YC*. The Evaluation and Structure Activities Relationships of 2-Benzoylamino-Benzoic Esters and Their Analogues as Anti-inflammatory and Anti-platelet Aggregation Agents. Bio. Med. Chem. Lett. 2007,17:1812-7.

* Corresponding author