俞松良 副教授

 
專長:
  1. 基因體學
  2. 腫瘤醫學
  3. 分子生物學
  4. 微生物學
 
現職:
  1. 國立台灣大學醫學檢驗暨生物技術學系副教授
  2. 國立臺灣大學附設醫院檢驗醫學部兼任醫檢師
 
學歷:
  1. 國立臺灣大學醫學院醫事技術學系學士
  2. 國立臺灣大學醫學院醫事技術研究所碩士
  3. 國立陽明大學微生物及免疫學研究所博士
 
電話: 886-2-23123456 #88697
傳真: 886-2-23958341
電子信箱: slyu@ntu.edu.tw
個人網址: http://www.mc.ntu.edu.tw/department/clsmb/teach_ft_slyu.html
 
簡介:
    俞松良副教授致力於功能性基因體研究,俞教授在十年間於台大基因體中心建立了多個功能性基因體研究平台,可用於分析:染色體DNA的變異、染色體的後生基因體調控、基因與微核醣核酸表現剖析、蛋白表現剖析、蛋白與DNA 交互作用、細胞學分析、藥物篩選平台等。曾獲得國科會「科學50」研究團隊、傑出技術移轉貢獻獎、經濟部生物科技研發成果創意應用競賽銀牌獎、國科會吳大猷先生紀念獎,並發表Cancer Cell、Cell Host & Microbe 和 Cancer Research等以及擁有多項國際專利。
 
代表性著作:
  1. Bing-Ching Ho*, Sung-Liang Yu*, Jeremy J.W. Chen, Sui-Yuan Chang, Bo-Shiun Yan, Qi-Sheng Hong, Sher Singh, Chuan-Liang Kao, Hsuan-Yu Chen, Kang-Yi Su, Ker-Chau Li, Chiou-Ling Cheng, Hao-Wei Cheng, Jen-Yi Lee, Chun-Nan Lee and Pan-Chyr Yang (2011) Enterovirus-induced miR-141 contributes to shutoff of host protein translation by targeting the translation initiation factor eIF4E. Cell Host & Microbe 20:58-69. 2011 (Ho BC and Yu SL equal contribution)
  2. Chen BZ*, Yu SL*, Singh S, Kao LP, Tsai ZY, Yang PC, Chen BH, Li SS. (2011) Identification of microRNAs expressed highly in pancreatic islet-like cell clusters differentiated from human embryonic stem cells. Cell Biol Int. 35:29-37 (Chen BZ and Yu SL equal contribution)
  3. Nakagawa-Goto K, Wu PC, Bastow KF, Yang SC, Yu SL, Chen HY, Lin JC, Goto M, Morris-Natschke SL, Yang PC, Lee KH. (2011) Antitumor agents 283. Further elaboration of Desmosdumotin C analogs as potent antitumor agents: Activation of spindle assembly checkpoint as possible mode of action. Bioorg Med Chem. 2011 Jan 15. [Epub ahead of print]
  4. Ou DL, Shen YC, Yu SL, Chen KF, Yeh PY, Fan HH, Feng WC, Wang CT, Lin LI, Hsu C, Cheng AL. (2010) Induction of DNA Damage-Inducible Gene GADD45{beta} Contributes to Sorafenib-Induced Apoptosis in Hepatocellular Carcinoma Cells. Cancer Res. 70:9309-18.
  5. Yu SL, Lin SB, Yu YL, Chien MH, Su KJ, Lin CJ, Way TD, Yiang GT, Lin CC, Chan DC, Harn HJ, Chen YL. (2010) Isochaihulactone protects PC12 cell against H(2)O(2) induced oxidative stress and exerts the potent anti-aging effects in D-galactose aging mouse model. Acta Pharmacol Sin. 31:1532-40
  6. Chang TH, Tsai MF, Su KY, Wu SG, Huang CP, Yu SL, Yu YL, Lan CC, Yang CH, Lin SB, Wu CP, Shih JY, Yang PC. (2010) Slug Confers Resistance to the Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor. Am J Respir Crit Care Med. 2010 Oct 29. [Epub ahead of print]
  7. Tsai ZY, Singh S, Yu SL, Chou CH, Li SS. (2010) A feeder-free culture using autogeneic conditioned medium for undifferentiated growth of human embryonic stem cells: comparative expression profiles of mRNAs, microRNAs and proteins among different feeders and conditioned media. BMC Cell Biol. 11:76.
  8. Lin PY, Yu SL*, Yang PC* (2010) MicroRNA in lung cancer. Br J Cancer. 103:1144-8. Review. (Yu SL and Yang PC equal contribution).
  9. Yang YL, Lin SR, Chen JS, Hsiao CC, Lin KH, Sheen JM, Cheng CN, Wu KH, Lin SW, Yu SL, Chen HY, Lu MY, Chang HH, Yen CT, Lin JF, Su YH, Li YP, Lin CY, Jou ST, Lin DT. (2010) Multiplex reverse transcription-polymerase chain reaction as diagnostic molecular screening of 4 common fusion chimeric genes in Taiwanese children with acute lymphoblastic leukemia. J Pediatr Hematol Oncol. 32:e323-30.
  10. Lin SY, Hsueh CM, Yu SL, Su CC, Shum WY, Yeh KC, Chang GC, Chen JJ. (2010) HLJ1 is a novel caspase-3 substrate and its expression enhances UV-induced apoptosis in non-small cell lung carcinoma. Nucleic Acids Res. 38:6148-58
  11. Cha ST, Chen PS, Johansson G, Chu CY, Wang MY, Jeng YM, Yu SL, Chen JS, Chang KJ, Jee SH, Tan CT, Lin MT, Kuo ML. (2010) MicroRNA-519c Suppresses Hypoxia-Inducible Factor-1{alpha} Expression and Tumor Angiogenesis. Cancer Res. 70: 2675-2685.
  12. Wang KH, Kao AP, Singh S, Yu SL, Kao LP, Tsai ZY, Lin SD, Li SS. (2010) Comparative expression profiles of mRNAs and microRNAs among human mesenchymal stem cells derived from breast, face, and abdominal adipose tissues. Kaohsiung J Med Sci. 26:113-22.
  13. Chen PM, Chen YY, Yu SL, Sher S, Lai CH, Chia JS (2010) GlnR-mediated acid-repression of glutamine/glutamate metabolism clusters in Streptococcus mutans. Applied and Environmental Microbiology 76: 2478-2486 (SCI).
  14. Yang YL, Lin SR, Chen JS, Lin SW, Yu SL, Chen HY, Yen CT, Lin CY, Lin JF, Lin KH, Jou ST, Hu CY, Chang SK, Lu MY, Chang HH, Chang WH, Lin KS, Lin DT. (2010) Expression and prognostic significance of the apoptotic genes BCL2L13, Livin, and CASP8AP2 in childhood acute lymphoblastic leukemia. Leukemia Research 34: 18-23. (SCI).
  15. Tzu-Pei Chang*, Sung-Liang Yu *, Sheng-Yi Lin, Yi-Jing Hsia, Gee-Chen Chang, Pan-Chyr Yang, Jeremy J.W. Chen (2010) Tumor suppressor HLJ1 switches the double-faced role of nucleophosmin through AP-2α complex formation Cancer Research 15: 1656-1667. (equal contribution). (SCI). IF: 7.514 (12/143)
  16. Yu, Yung-Luen*; Yu, Sung-Liang*; Su, Kuo-Jung; Wei, Chyou-Wei; Jian, Min-Hui; Lin, Po-Cheng; Tsen, I-Hsuan; Lin, Chai-Ching; Su, Chin-Cheng; Chang, Wen-Liang; Lin, Shinn-Zong; Harn, Horng-Jyh; Chen, Yi-Lin. (2010) Extended MGMT promoter hypermethylation following n-Butylidenephthalide combined with 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) on inhibition of HCC carcinoma cells growth. Journal of Agricultural and Food Chemistry  58: 1630-1638. (equal contribution). (SCI). IF: 2.562 (2/35)
  17. Zong-Yun Tsai, Sher Singh, Sung-Liang Yu, Li-Pin Kao, Bo-Zhi Chen, Bing-Ching Ho, Pan-Chyr Yang and Steven Shoei-Lung Li. (2010) Identification of microRNAs regulated by activin A in human embryonic stem cells. Journal of Cellular Biochemistry. 109:93-102.
  18. Hsu YC, Yuan S, Chen HY, Yu SL, Liu CH, Hsu PY, Wu G, Lin CH, Chang GC, Li KC, Yang PC. (2009) A Four-Gene Signature from NCI-60 Cell Line for Survival Prediction in Non-Small Cell Lung Cancer. Clin Cancer Res. 15: 7309-7315.
  19. Ou DL, Shen YC, Liang JD, Liou JY, Yu SL, Fan HH, Wang DS, Lu YS, Hsu C, Cheng AL. 2009. Induction of Bim expression contributes to the antitumor synergy between sorafenib and mitogen-activated protein kinase/extracellular signal-regulated kinase kinase inhibitor CI-1040 in hepatocellular carcinoma. Clin Cancer Res. 15:5820-8.
  20. Kao LP, Yu SL, Singh S, Wang KH, Kao AP, and Li SSL. 2009. Comparative Profiling of mRNA and microRNA Expression in Human Mesenchymal Stem Cells Derived from Adult Adipose and Lipoma Tissues. The Open Stem Cell Journal. 1(9):1-9. (equal contribution) (Original article).
  21. Lin JC, Yang SC, Hong TM, Yu SL, Shi Q, Wei L, Chen HY, Yang PC, Lee KH. (2009) Phenanthrene-Based Tylophorine-1 (PBT-1) Inhibits Lung Cancer Cell Growth through the Akt and NF-kappaB Pathways. J Med Chem. 52: 1903-1911. (SCI). (Original article).
  22. Steven Shoei-Lung Li, Sung-Liang Yu, Li-Pin Kao, Zong Yun Tsai, Sher Singh, Bo Zhi Chen, Bing-Ching Ho, Yung-Hsien Liu and Pan-Chyr Yang. (2009) Target identification of microRNAs expressed highly in human embryonic stem cells. Journal of Cellular Biochemistry. 106; 1020-30. (SCI). (Original article).
  23. Wan-Hsin Liu, Shiou-Hwei Yeh, Cho-Chun Lu, Sung-Liang Yu, Hsuan-Yu Chen, Chien-Yu Lin, Ding-Shinn Chen and Pei-Jer Chen. (2009) Elevation of MicroRNA-18a Downregulates Estrogen Receptor Alpha and Stimulates Hepatocyte Proliferation in Female Hepatocellular Carcinoma. Gastroenterology. 136; 683-93. (SCI). (Original article).
  24. Yu-Chih Chao, Szu-Hua Pan, Shuenn-Chen Yang, Sung-Liang Yu, Che-Hsiang Wu, Chung-Wu Lin, Mu-shiun Tsai, Gee-Chen Chang, Ting-Fang Che, Yi-Ying Wu, Tse-Ming Hong, and Pan-Chyr Yang. (2009) Claudin-1 is a Metastasis Suppressor and Correlates with Clinical Outcome in Lung Adenocarcinoma. Am. J. Respir. Crit. Care Med. 179; 123-33. (SCI). (Original article).
  25. Chen HW, Jen-Yi Lee, Ji-Ying Huang, Chi-Chung Wang , Wan-Jiun Chen, Sheng-Fang Su, Chia-Wen Huang, Chao-Chi Ho, Meng-Feng Tsai, Sung-Liang Yu, Jeremy JW Chen, and Pan-Chyr Yang (2008) Curcumin Inhibits Lung Cancer Cell Invasion and Metastasis through the Tumor Suppressor HLJ1 Cancer Research 68; 7428-38. (SCI). (Original article).
  26. Sung-Liang Yu, Sher Singh, PhD, Huei-Wen Chen, Hsuan-Yu Chen, Jeremy J.W. Chen, Wen-Jone Chen, Han-Shiang Chen, Shyr-Chyr Chen. (2008) Intra-abdominal Adhesion Formation Induces Anti-oxidative Injury, Enhances Cell Proliferation, and Prevents Complement-mediated Lysis. Wound Repair and Regeneration 16; 388-98. (SCI). (Original article).
  27. Sung-Liang Yu, Hsuan-Yu Chen, Gee-Chen Chang, Chih-Yi Chen, Huei-Wen Chen, Sher Singh, Chiou-Ling Cheng, Chong-Jen Yu, Yung-Chie Lee, Han-Shiang Chen, Te-Jen Su, Ching-Cheng Chiang, Han-Ni Li, Qi-Sheng Hong, Hsin-Yuan Su, Chun-Chieh Chen, Wan-Jiun Chen, Chun-Chi Liu, Wing-Kai Chan, Wei J. Chen, Ker-Chau Li, Jeremy J.W. Chen, and Pan-Chyr Yang. (2008) MicroRNA Signature Predicts Survival and Relapse in Lung Cancer. Cancer Cell 13; 48-57 (SCI). (Original article).
  28. Liu YL, Fann CS, Liu CM, Chang CC, Yang WC, Hung SI, Yu SL, Hwang TJ, Hsieh MH, Liu CC, Tsuang MM, Wu JY, Jou YS, Faraone SV, Tsuang MT, Chen WJ, Hwu HG. (2007) More evidence supports the association of PPP3CC with schizophrenia. Mol Psychiatry 12; 966-974 (SCI). (Original article).
  29. Yu SL, Chen HY, Yang PC*, and Chen JJW* (2007) Unique MicroRNA Signature and Clinical Outcome of Cancers. DNA and Cell Biology 26: 283-292 (SCI). (Review).
  30. Hsuan-Yu Chen, Sung-Liang Yu, Chun-Houh Chen, Gee-Chen Chang, Chih-Yi Chen, Ang Yuan, Chiou-Ling Cheng, Chien-Hsun Wang, Harn-Jing Terng, Shu-Fang Kao, Wing-Kai Chan, Han-Ni Li, Chun-Chi Liu, Sher Singh, Wei J. Chen, Jeremy J.W. Chen, Pan-Chyr Yang (2007) A 5-Gene Signature and Clinical Outcome of Non-small Cell Lung Cancer. N Engl J Med 356: 11-20 (SCI). (Original article).
  31. Sher Singh,Hsiu-Yi Ou Yang, Mei-Ying Chen, Sung-Liang Yu* (2007) A Kinetic-Dynamic Model for Regulatory RNA Processing. Journal of Biotechnology 127:488-495 (SCI). (Original article, Corresponding Author).
  32. Huei-Wen Chen, Sheng-Fang Su, Chiang-Ting Chien, Wei-Hsiang Lin, Sung-Liang Yu, Cheng-Chung Chou, Jeremy J.W. Chen, and Pan-Chyr Yang (2006) Titanium Dioxide Nanoparticles Induce Emphysema-like Lung Injury in Mice. FASEB J 20(13): 2393 – 2395 (SCI). (Original article).
  33. Sung-Liang Yu (2005) ABC’s of microarray. Formosan Journal of Medicine 9 (5):603-613. (Original article).
  34. Wen-Chien Chou, Hsuan-Yu Chen, Sung-Liang Yu, Linzhao Cheng, Pan-Chyr Yang, Chi V. Dang. (2005) Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood 106:304-310 (SCI). (Original article).
  35. Chen WJ, Chen HW, Yu SL, Huang CH, Wang TD, Chen JJ, Chien CT, Chen HY, Yang PC, Lee YT. (2005). Gene Expression Profiles in Hypoxic Preconditioning using cDNA Microarray Analysis: Altered Expression of an Angiogenic Factor, CEACAM-1. Shock 24: 124-131 (SCI). (Original article).
  36. Huei-Wen Chen, Jeremy J.W. Chen, Sung-Liang Yu, Han-Ni Li, Pan-Chyr Yang, Ching-Mao Su, Heng-Kien Au, Ching-Wen Chang, Li-Wei Chien, Chieh-Sheng Chen, and Chii-Ruey Tzeng (2005). Transcriptomic analysis during blastocyst hatching by cDNA microarrray. Human Reproduction 20:2492-2501 (SCI). (Original article).
  37. Sung-Liang Yu, Huei-Wen Chen, Pan-Chyr Yang, Konan Peck, Min-Hui Tsai, Jeremy J.W. Chen, and Fang-Yue Lin. (2004) Differential Gene Expression in Gram-negative and Gram-positive Sepsis. Am. J. Resp. Crit. Care Med. 169:1135-1143. (SCI). (Original article).
  38. Chen, HW, Yu, SL, Chen, WJ, Yang, PC, Tzeng, CR, Li, HN, Peck, K, Chen, JJW, Lee, YT. (2004). Profiling of Gene Expression Pattern during Postnatal Myocardial Development by cDNA Microarray. Heart 90:927-934. (equal contribution). (SCI). (Original article).
  39. Chen HW, Yu SL, Chen JJW, Li HN, Lin YC, Yao PL, Chou HY, Chien CT, Chen WJ, Lee YT, and Yang PC. (2004) Anti-Invasive Gene Expression Profile of Curcumin in Lung Adenocarcinoma Based on a High Throughput Microarray Analysis. Mol. Pharmacol. 65: 99-110. (SCI). (Original article).