詹迺立 副教授

 
專長:
  1. 結構生物學
  2. 第二型DNA拓樸異構酵素(type II topoisomerases)之結構與功能
  3. 生物巨分子複合體之組裝與結構功能解析
 
現職:
  • 國立臺灣大學醫學院 生物化學暨分子生物學研究所 副教授
 
學歷:
  • 國立臺灣大學化學系學士
  • 美國愛荷華大學生物化學研究所博士
 
電話: 886-2-23123456 #88213
傳真: 886-2-23915295
電子信箱: nlchan@ntu.edu.tw
個人網頁: http://www.mc.ntu.edu.tw/department/ibmb/chinese/teacher/ChanNeiLi/ChanNL_set.html
 
代表性著作:
  1. Lee, C.-H., Hsieh, M.-Y., Hsin, L.-W., Chen, H.-C., Lo, S.-C., Fan, J.-R., Chen, W.-R., Chen, H.-W., Chan, N.-L.*, and Li, T.-K.* (2012) Anthracenedione-methionine conjugates are novel topoisomerase II-targeting anticancer agents with favorable drug resistance profiles. Biochem. Pharmacol. 83:1208-16.
  2. Wu, C.-C., Li, T.-K., Farh, L., Lin, L.-Y., Lin, T.-S., Yu, Y.-J., Yen, T.-J., Chiang, C.-W., & Chan, N.-L.* (2011) Structural basis of type II topoisomerase inhibition by the anticancer drug etoposide. Science, 333:459-62.
  3. Chen, C. K.-M., Chan, N.-L.*, & Wang, A. H.-J.* (2011) The many blades of the b-propeller proteins: conserved but versatile. Trends Biochem. Sci. 36:553-61.
  4. Hsieh, T.-J., Yen, T.-J., Lin, T.-S., Chang, H.-T., Huang, S.-Y., Hsu, C.-H., Farh, L., Chan, N.-L.* (2010) Twisting of the DNA binding surface by a b-strand-bearing proline modulates DNA gyrase activity. Nu cleic Acids Research, 38:4173-81.
  5. Li, Y.-C., Chiang, C.-W., Yeh, H.-C., Hsu, P.-Y., Whitby, F. G., Wang, L.-H., and Chan, N.-L.* (2008) Structures of Prostacyclin Synthase and Its Complexes with Substrate Analog and Inhibitor Reveal a Ligand-specific Heme Conformation Change. J. Biol. Chem. 283: 2917-26.