Professor Yang-Chang Wu

 
Specialty:
  1. Natural Medicine
  2. New drug development of Chinese Medicine
 
Current Position:
  • Vice President, China Medical University, Taiwan
  • Chair Professor, Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taiwan
 
Education:
  • Doctor of Philosophy, Kaohsiung Medical University, Taiwan
  • Master of Science, Kaohsiung Medical University, Taiwan
  • Bachelor of Science in Pharmacy, Kaohsiung Medical University, Taiwan
 
Tel: 04-22057153
Fax: 04-22060428
E-mail: yachwu@mail.cmu.edu.tw
 
Introduction:
    Professor Yang-Chang Wu is currently Vice President and Chair Professor of CMU and, has served as Director of Graduate Institute of Natural Products, Dean of Office of Research and Development and Chair Professor of Kaohsiung Medical University, Department Chairmen of Pharmacy and Chinese Medicine, National Science Council (NSC) and Consultant of Committee on Chinese Medicine and Pharmacy, Department of Health, Executive Yuan. Prof. Wu has received the Outstanding Research Award of NSC, Outstanding Merit and High Scholastic Achievement to Medical and Pharmaceutical Research Award of Ming-Ning Wang Foundation and Outstanding Medical and Pharmaceutical Technology Award of Tien Te Lee Biomedical Foundation. Prof. Wu has published 380 papers, many ranking in the top 10% in the field; his papers have been cited more than 2,000 times. In particular, Prof. Wu developed the compound from Chinese herbal medicine, Furula, against H1N1 and published this result in Journal of Natural Products, which was chosen as breaking news in 2009. In recent years, Prof. Wu has been devoted to research of cancer molecular biology and signal transduction in order to improve drug development and cancer therapy. Overall, he is a distinguished researcher in transferring basic research to clinical applications.
 
Selected Publication:
  1. Zeng YF, Wa JQ, Shi LY, Wang K, Zhou B, Tang Y, Zhang DY*, Wu YC, Hua WY, and Wu XM. Synthesis and evaluation of cytotoxic effects of novel α-methylenelactone tetracyclic diterpenoids. Bioorg Med Chem Lett. 2012,22:1922-5.
  2. Chao CH, Chou KJ, Huang CY, Wen ZH, Hsu CH, Wu YC, Dai CF, and Sheu JH*. Steroids from the Soft Coral Sinularia crassa. Mar Drugs 2012,10:439-50.
  3. Lan YH*, Peng YT, Thang TD, Hwang TL, Dai DN, Leu YL, Lai WC, and Wu YC*. New Flavan and Benzil Isolated from Fissistigma latifolium. Chem. Pharm. Bull. 2012,60:280-2.
  4. Hsu CC, Wu YC, Farh L, Du YC, Tseng WK, Wu CC, and Chang FR*. Physalin B from Physalis angulata triggers the NOXA-related apoptosis pathway of human melanoma A375 cells. Food and Chemical Toxicology 2012,50:619-24.
  5. Chung YM, Chang FR, Tseng TF, Hwang TL, Chen LC, Wu SF, Lee CL, Lin ZY, Chuang LY, Su JH*, and Wu YC*. A novel alkaloid, aristopyridinone A and anti-inflammatory phenanthrenes isolated from Aristolochia manshuriensis. Bioorg. Med. Chem. Lett.2011, In press.
  6. Chen HM, Chang FR, Hsieh YC, Cheng YJ, Hsieh KC, Tsai LM, Lin AS, Wu YC*, and Yuan SS*. A novel synthetic protoapigenone analogue, WYC02-9, induces DNA damage and apoptosis in DU145 prostate cancer cells through generation of reactive oxygen species. Free Radic. Bio. Med.2011, In press.
  7. Chen WY, Hsieh YA, Tsai CI, Kang YF, Chang FR, Wu YC*, and Wu CC*. Protoapigenone, a natural derivative of apigeninm, induces mitogen-activated protein kinase-dependent apoptosis in human breast cancer cells associated with induction of oxidative stress and inhibition of glutathione S-transferasep. Invest New Drugs 2011, In press.
  8. Lee CC, Lin YH, Chang WH, Lin PC, Wu YC*, and Chang JG. Squamocin modulates histone H3 phosphorylation levels and induces G1 phase arrest and apoptosis in cancer cells. BMC Cancer 2011,11:58.
  9. Lee JC*, Chen WC, Wu SF, Tseng CK, Chiou CY, Chang FR, Hsu SH, and Wu YC*. Anti-hepatitis C virus activity of Acacia confuse extract via suppressing cyclooxygenase-2. Antiviral Res. 2011,89:35-42.
  10. Lee CL, Huang CH, Wang HC, Chuang DW, Wu MJ, Wang SY, Hwang TL, Wu CC, Chen YL, Chang FR*, and Wu YC*. First total synthesis of antrocamphin A and its analogs as anti-inflammatory and anti-platelet aggregation agents. Org. Biomol. Chem. 2011,9 (1), 70-3.
  11. Lee CL, Liao YC, Hwang TL, Wu CC, Chang FR*, and Wu YC*. Ixorapeptide I and ixorapeptide II, bioactive peptides isolated from Ixora coccinea. Bioorg. Med. Chem. Lett. 2010,20:7354-7.
  12. Shih YT, Chen PS, Wu CH, Tseng YT, Wu YC*, and Lo YC*. Arecoline, a major alkaloid of the areca nut, causes neurotoxicity through enhancement of oxidative stress and suppression of the antioxidant protectivesystem. Free Radic. Bio. Med. 2010,49:1471-9.
  13. Liaw CC, Wu TY, Chang FR, and Wu YC*. Historic Perspectives on Annonaceous Acetogenins from the Chemical Bench to Preclinical Trials. Planta Med. 2010,76(13), 1390-404.
  14. Chang CL, Zhang LJ, Chen RY, Kuo LM, Huang JP, Huang HC, Lee KH, Wu YC* and Kuo YH*. Antioxidant and anti-inflammatory phenylpropanoid derivatives from Calamus quiquesetinervius. J. Nat. Prod. 2010,73(9):1482-8.
  15. Yen CY, Chiu CC, Chang FR, Chen JYF, Hwang CC, Hseu YC, Yang HL, Lee AYL, Tsai MT, Guo ZL, Cheng YS, Liu YC, Lan YH, Chang YC, Ko YC, Chang HW*, and Wu YC*. 4beta-Hydroxywithanolide E from Physalis peruviana (golden berry) inhibits growth of human lung cancer cells through DNA damage, apoptosis and G2/M arrest. BMC Cancer 2010,10:46 (8 pages)
  16. Yen CT, Wu CC, Lee JC, Chen SL, Morris-Natschke SL, Hsieh PW*, and Wu YC*. Cytotoxic N-(fluorenyl-9-methoxycarbonyl) (Fmoc)-dipeptides: Structure-activity relationships and synergistic studies. Eur. J. Med. Chem. 2010,45:2494-502.
  17. Yang PY, Chen MF, Tsai CH, Hu DN, Chang FR, and Wu YC*. Involvement of caspase and MAPK activities in norcantharidin-inducedcolorectal cancer cell apoptosis. Toxicology in Vitro 2010,24:766-75.
  18. Chang CL, Wang GJ, Zhang LJ, Tsai WJ, Chen RY, Wu YC*, and Kuo YH*. Cardiovascular protective flavonolignans and flavonoids from Calamus quiquesetinervius. Phytochemistry 2010,71:271-9.
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  20. Lee CL, Chiang LC, Cheng LH, Liaw CC, Abd El-Razek MH, Chang FR*, and Wu YC*. Anti-influenza A Viral (H1N1) and Cytotoxic Agents from Ferula assafoetida. J. Nat. Prod. 2009, 72:1568-72.
  21. Lan YH, Chang FR*, Pan MJ, Wu CC, Wu SJ, Chen SL, Wang SS, Wu MJ, and Wu YC*. New Cytotoxic Withanolides from Physalis peruviana. Food Chemistry 2009,116:462-9.
  22. Du YC, Lin AS, Wu CC, Hsieh PW, Chen YH, Chen IH, Chen SL, Yen HF, Lübken T, Chang FR*, and Wu YC*. New Cytotoxic Lupane Triterpenes from Perrottetia arisanensis. Planta Med.2009,75:848-55.
  23. Chen IH, Lu MC, Du YC, Yen MH, Wu CC, Chen YH, Hung CS, Chen SL, Chang FR* and Wu YC*. Cytotoxic Triterpenoids from the Stems of Microtropis japonica. J. Nat. Prod.2009,72:1231-6.
  24. Lin AS, Lin CR, Du YC, Lübken T, Chiang MY, Chen IH, Wu CC, Hwang TL, Chen SL, Yen MH, Chang FR*, and Wu YC*. Acasiane A and B and Farnesirane A and B, Diterpene Derivatives from the Roots of Acacia farnesiana. Planta Med.2009,75:256-61.
  25. Yen CT, Hwang TL, Wu YC*, and Hsieh PW*. Design and synthesis of new N-(fluorenyl-9-methoxycarbonyl) (Fmoc)-dipeptides as anti-inflammatory agents. Eur. J. Med. Chem. 2009,44:1933-40.
  26. Lee CL, Chang FR, Yen MH, Yu D, Liu YN, Bastow KF, Morris-Natschke SL, Wu YC* and Lee KH*. Cytotoxic phenanthrenequinones and 9,10-dihydrophenanthrenes from Calanthe arisanensis. J. Nat. Prod. 2009,72:210-3.
  27. Lu MC, Hwang SL, Chang FR, Chen YH, Hung CS, Wang CL, Chu YH, Pan SJ, and Wu YC*. Immunostimulatory effect of Antrodia cinnamomea extract on functional maturation of dendritic cells. Food Chemistry 2009,113:1049-57.
  28. Hsu HF, Houng JY*, Kuo CF, Tsaod N, and Wu YC*. Glossogin, a novel phenylpropanoid from Glossogyne tenuifolia, induced apoptosis in A549 lung cancer cells. Food Chem Toxicol.2008,46:3785-91.
  29. Chuang PH, Hsieh PW, Yang YL, Hua KF, Chang FR, Shiea J, Wu SH, and Wu YC*. Cyclopeptides with anti-inflammatory activities from the seeds of Annona montana. J. Nat. Prod. 2008,71:1365-70.
  30. Chen IH, Du YC, Lu MC, Hsieh PW, Wu CC, Chen SL, Yen HF, Chang FR*, and Wu YC*. New Lupane-type Triterpenoids from Microtropis fokienensis and Perrottetia arisanensis and Apoptotic Effect of 28-hydroxy-3-oxo-lup-20(29)-en-30-al. J. Nat. Prod. 2008,71:1352-7.
  31. Chen YL, Lan YH, Hsieh PW, Wu CC, Chen SL, Yen CT, Chang FR*, Hung WC, and Wu YC*. Bioactive Cembrane Diterpenoids of Anisomeles indica. J. Nat. Prod. 2008,71:1207-12.
  32. Chang HL, Su JH, Yeh YT, Lee YC, Chen HM, Wu YC*, and Yuan SSF*. Protoapigenone, a novel flavonoid, inhibits ovarian cancer cell growth in vitro and in vivo. Cancer Lett. 2008,267:85-95.
  33. Chen WY, Chang FR, Huang ZY, Chen JH, Wu YC*, and Wu CC*. Tubocapsenolide A, A Novel Withanolide, Inhibits Proliferation and Induces Apoptosis in MDA-MB-231 cells by Thiol Oxidation of Heat Shock Proteins. J. Biol. Chem. 2008,283:17184-93.
  34. Liaw CC, Yang YL, Chen M, Chang FR*, Chen SL, and Wu YC*. Mono-Tetrahydrofuran Annonaceous Acetogenins from Annona squamosa as Cytotoxic Agents and Calcium Ion Chelators. J. Nat. Prod. 2008,71:764-71.
  35. Yang YL, Hua KF, Chuang PH, Wu SH, Wu KY, Chang FR, and Wu YC*. New cyclic peptides from the seeds of Annona squamosa L. and their anti-inflammatory activities. J. Agric. Food Chem. 2008,56:386-92.
  36. Lee CL, Chang FR, Hsieh PW, Chiang MY, Wu CC, Huang ZY, Lan YH, Chen M, Lee KH, Yen HF, Hung WC, Wu YC*. Cytotoxic ent-abietane diterpenes from Gelonium aequoreum. Phytochemistry 2008,69:276-87.
  37. Yang YL, Chang SM, Wu CC, Hsieh PW, Chen SL, Chang FR*, Hung WC, Issa HH, and Wu YC*. Cytotoxic Sesquiterpene Lactones from Pseudoelephantopus spicatus. J. Nat. Prod. 2007,70:1761-5.
  38. Wang WY, Hsieh PW, Wu YC*, Wu CC*. Synthesis and pharmacological evaluation of novel _-nitrostyrene derivatives as tyrosine kinase inhibitors with potent antiplatelet activity. Biochemical Pharmacology. 2007,74:601-11.
  39. Lin AS, Nakagawa-Goto K, Chang FR, Yu D, Morris-Natschke SL, Wu CC, Chen SL, Wu YC*, and Lee KH*. First Total Synthesis of Protoapigenone and its Analogs as Potent Cytotoxic Agents. J. Med. Chem. 2007,50:3921-7.
  40. Chang HC*, Chang FR, Wu YC, Pan MR, Hung WC, and Wu YC*. A Bioactive Withanolide Tubocapsanolide A inhibits proliferation of human lung cancer cells via repressing Skp2 expression.” Mol. Cancer Ther. 2007,6:1572-8.
  41. Hsieh PW, Huang ZY, Chen JH, Chang FR*, Wu CC, Yang YL, Chiang MY, Yen MH, Chen SL, Yen HF, Lübken T, Hung WC, and Wu YC*. Cytotoxic Withanolides from Tubocapsicum anomalum. J. Nat. Prod. 2007,70:747-53.
  42. Lin AS, Chang FR, Yen HF, Björkeborn HMa, Norlen P, and Wu YC*. Novel Flavonoids of Thelypteris torresiana. Chem. Pharm. Bull. 2007,55(4):635-7.
  43. Hsieh PW, Hwang TL, Wu CC, Chiang SZ, Wu CI, and Wu YC*. The Evaluation and Structure Activities Relationships of 2-Benzoylamino-Benzoic Esters and Their Analogues as Anti-inflammatory and Anti-platelet Aggregation Agents. Bio. Med. Chem. Lett. 2007,17:1812-7.

* Corresponding author