Professor Pan-Chyr Yang

  1. Internal and Thoracic Medicine
  2. Oncology
  3. Molecular and Cellular Biology
  4. Ultrasonics
  5. Cancer genomics
Current Position:
  • Dean of National Taiwan University College of Medicine
  • Professor, Department of Internal Medicine, National Taiwan University College of Medicine
  • M.D., Department of Medicine, National Taiwan University College of Medicine
  • Ph.D., Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine
Tel: 886-2-23562185
Fax: 886-2-23224793
    Professor Pan-Chyr Yang is an expert in both basic and clinical research, is committed to lung cancer genomic research and has had fruitful achievements on the mechanisms of pathogenesis and metastasis of lung cancer. The research group led by Prof. Yang has published in a number of journals including high impact well-known international journals, such as the New England Journal of Medicine, Cancer Cell, Nature Cell Biology, the Journal of Clinical Oncology, the Journal of the National Cancer Institute, Cell Host & Microbe, the American Journal of Respiratory and Critical Care Medicine and Blood and was honorably selected in 'Science 50' by NSC. Prof. Yang serves as Dean of NTUCM, Director of National Research Program for Biopharmaceuticals and President of Taiwan Society of Pulmonary and Critical Care Medicine. Prof. Yang has received a number of distinguished awards, such as Outstanding Academic Research Award recognized by NSC, Outstanding Merit and High Scholastic Achievement Award recognized by Wang Ming-Ning Memorial Foundation, Outstanding Professor Award recognized by Far Eastern YZ Hsu Science and Technology Memorial Foundation, Distinguished Teacher Award from NTU and Academic Award from Ministry of Education; he was awarded Academician of Academia Sinica and The Academy of Sciences for the Developing World.
Selected Publications:
  1. Kao SH, Wang WL, Chen CY, Chang YL, Wu YY, Wang YT, Wang SP, Nesvizhskii AI, Chen YJ, Hong TM, Yang PC. GSK3β controls epithelial-mesenchymal transition and tumor metastasis by CHIP-mediated degradation of Slug. Oncogene. 2013. doi: 10.1038
  2. Chen CY, Jan CI, Lo JF, Yang SC, Chang YL, Pan SH, Wang WL, Hong TM, Yang PC. Tid1-L inhibits EGFR signaling in lung adenocarcinoma by enhancing EGFR Ubiquitinylation and degradation. Cancer Res. 2013; 73(13): 4009-19.
  3. Lin CW, Chang YL, Chang YC, Lin JC, Chen CC, Pan SH, Wu CT, Chen HY, Yang SC, Hong TM, Yang PC. MicroRNA-135b promotes lung cancer metastasis by regulating multiple targets in the Hippo pathway and LZTS1. Nat Commun. 2013; 4: 1877.
  4. Chang YC, Yang CY, Sun RL, Cheng YF, Kao WC, Yang PC. Rapid single cell detection of Staphylococcus aureus by aptamer-conjugated gold nanoparticles. Sci Rep. 2013; 3: 1863.
  5. Hung PF, Hong TM, Hsu YC, Chen HY, Chang YL, Wu CT, Chang GC, Jou YS, Pan SH, Yang PC. The motor protein KIF14 inhibits tumor growth and cancer metastasis in lung adenocarcinoma. PLoS One. 2013; 8(4): e61664.
  6. Hsu YC, Chen HY, Yuan S, Yu SL, Lin CH, Wu G, Yang PC, Li KC. Genome-wide analysis of three-way interplay among gene expression, cancer cell invasion and anti-cancer compound sensitivity. BMC Med. 2013; 11: 106.
  7. Chen JS, Chan WK, Tsai KT, Hsu HH, Lin CY, Yuan A, Chen WJ, Lai HS, Yang PC. Simple aspiration and drainage and intrapleural minocycline pleurodesis versus simple aspiration and drainage for the initial treatment of primary spontaneous pneumothorax: an open-label, parallel-group, prospective, randomised, controlled trial. Lancet. 2013; 381(9874): 1277-82.
  8. Lin CW, Tseng SJ, Kempson IM, Yang SC, Hong TM, Yang PC. Extracellular delivery of modified oligonucleotide and superparamagnetic iron oxide nanoparticles from a degradable hydrogel triggered by tumor acidosis. Biomaterials. 2013; 34(17): 4387-93.
  9. Lin JC, Wu YY, Wu JY, Lin TC, Wu CT, Chang YL, Jou YS, Hong TM, Yang PC. TROP2 is epigenetically inactivated and modulates IGF-1R signalling in lung adenocarcinoma. EMBO Mol Med. 2012; 4(6): 472-85.
  10. Wang WL, Hong TM, Chang YL, Wu CT, Pan SH, Yang PC. Phosphorylation of LCRMP-1 by GSK3β promotes filopoda formation, migration and invasion abilities in lung cancer cells. PLoS One. 2012; 7(2): e31689.
  11. Kang-Yi Su, Hsuan-Yu Chen, Ker-Chau Li, Min-Liang Kuo, James Chih-Hsin Yang, Wing-Kai Chan, Bing-Ching Ho, Gee-Chen Chang*, Jin-Yuan Shih*, Sung-Liang Yu*, and Pan-Chyr Yang. (2012) Pretreatment Epidermal Growth Factor Receptor (EGFR) T790M Mutation Predicts Shorter EGFR Tyrosine Kinase Inhibitor Response Duration in Patients With Non-Small-Cell Lung Cancer. Journal of Clinical Oncology. 2012 Jan 3. [Epub ahead of print]
  12. Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger K, Yatabe Y, Powell CA, Beer D, Riely G, Garg K, Austin JH, Rusch VW, Hirsch FR, Jett J, Yang PC, Gould M. International association for the study of lung cancer/American Thoracic Society/European Respiratory Society: international multidisciplinary classification of lung adenocarcinoma: executive summary. Proc Am Thorac Soc. 2011 Sep;8(5):381-5
  13. Hsieh WY, Chou CC, Ho CC, Yu SL, Chen HY, Chou HY, Chen JJ, Chen HW, Yang PC. Single-Walled Carbon Nanotubes Induce Airway Hyper-Reactivity and Parenchymal Injury in Mice. Am J Respir Cell Mol Biol. 2011 Sep 29. [Epub ahead of print]
  14. Ho MJ, Yu KH, Hirsh D, Huang TS, Yang PC. Does One Size Fit All? Building a Framework for Medical Professionalism. Acad Med. 2011Nov;86(11):1407-1414.
  15. Lee MR, Keng LT, Shu CC, Lee SW, Lee CH, Wang JY, Lee LN, Yu CJ, Yang PC. Risk factors for Mycobacterium chelonae-abscessus pulmonary disease persistence and deterioration. J Infect. 2011 Nov 12. [Epub ahead of print]
  16. Lee JY, Lee YM, Chang GC, Yu SL, Hsieh WY, Chen JJ, Chen HW, Yang PC. Curcumin induces EGFR degradation in lung adenocarcinoma and modulates p38 activation in intestine: the versatile adjuvant for gefitinib therapy. PLoS One. 2011;6(8):e23756. Epub 2011 Aug 17.
  17. Su KY, Chen HY, Li KC, Kuo ML, Yang James CH, Chan WK, Ho BC, Chang GC, Shih JY, Yu SL, Yang PC: Pre-treatment EGFR T790M mutation predicts shorter EGFR-TKI response duration in NSCLC patients. J Clin Oncol 2011 (in press)
  18. Yang X, Shi Q, Yang SC, Chen CY, Yu SL, Bastow KF, Morris-Natschke SL, Wu PC, Lai CY, Wu TS, Pan SL, Teng CM, Lin JC, Yang PC, Lee KH: Antitumor agents 288: design, synthesis, SAR, and biological studies of novel heteroatom-incorporated antofine and cryptopleurine analogues as potent and selective antitumor agents. J Med Chem. 2011 Jul 28;54(14):5097-107.
  19. Liu YC, Yen HY, Chen CY, Chen CH, Cheng PF, Juan YH, Chen CH, Khoo KH, Yu CJ, Yang PC, Hsu TL, Wong CH. Sialylation and fucosylation of epidermal growth factor receptor suppress its dimerization and activation in lung cancer cells. Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11332-7.
  20. Lai CY, Yu SL, Hsieh MH, Chen CH, Chen HY, Wen CC, Huang YH, Hsiao PC, Hsiao CK, Liu CM, Yang PC, Hwu HG, Chen WJ: MicroRNA expression aberration as potential peripheral blood biomarkers for schizophrenia. PLoS One. 2011;6(6):e21635. Epub 2011 Jun 29.
  21. Tsai TH, Su KY, Wu SG, Chang YL, Luo SC, Jan IS, Yu CJ, Yu SL, Shih JY, Yang PC: RNA is Favorable for Analyzing EGFR Mutations in Malignant Pleural Effusion of Lung Cancer. Eur Respir J. Epub 2011 Jun 30.
  22. Chung KP, Huang YT, Chang YL, Yu CJ, Yang CH, Chang YC, Shih JY, Yang PC: Clinical Significance of TTF-1 in Advanced Lung Adenocarcinoma under EGFR Tyrosine Kinase Inhibitor Treatment. Chest. Epub 2011 Jul 28.
  23. Lee JY, Lee YM, Chang GC, Yu SL, Hsieh WY, Chen JJ, Chen HW, Yang PC: Curcumin induces EGFR degradation in lung adenocarcinoma and modulates p38 activation in intestine: The versatile adjuvant for gefitinib therapy. PLoS One. 2011;6(8):e23756. Epub 2011 Aug 17
  24. Shih JY, Yang PC: The EMT regulator Slug and lung carcinogenesis. Carcinogenesis 2011;32: 1299-304.
  25. Chen PS, Su JL, Cha ST, Tarn WY, Wang MY, Hsu HS, Lin MT, Chu CY, Hua KT, Chen CN, Kuo TC, Chang KJ, Hsiao M, Chen JS, Yang PC, Kuo ML: MiR-107 promotes tumor progression by targeting the Let-7 microRNA in mice and humans. J Clin Invest 2011;21(9):3442-55.
  26. Lin PY, Yang PC: Circulating miRNA signature for early diagnosis of lung cancer. EMBO Molecular Medicine 2011;8:436-7
  27. Pan SH, Chao YC, Hung PH, Chen HY, Yang SC, Chang YL, Wu CT, Chang CC, Wang WL, Chan WK, Wu YY, Che TF, Wang LK, Lin CY, Lee YC, Kuo ML, Lee CH, Chen JJW, Hong TM, Yang PC: The ability of LCRMP-1 to promote cancer invasion by enhancing filopodia formation is antagonized by CRMP-1. J Clin Invest 2011;121(8):3189-205.
  28. Yuan SS, Chen HY, Hsu YC, Su KY, Chang GC, Chen HW, Chen CY, Yu CJ, Shih JY, Lee YC, Chang YL, Cheng CL, Hsu CP, Hsia JY, Lin CY, Wu G, Liu CH, Wang CD, Yang KC, Chen YW, LaiYL, Hsu CC, Lin TJ, Yang TY, Chen KC, Hsu KH, Chen JJW, Yu SL, Li KC, Yang PC: Clustered genomic alterations in chromosome 7p dictate outcomes and targeted treatment responses of lung adenocarcinoma with EGFR-activating mutations. J Clin Oncol 2011;29(25):3435-42
  29. Wu YY, Peck K, Chang YL, Pan SH, Cheng YF, Lin JC, Yang RB, Hong TM, Yang PC: SCUBE3 is an endogenous TGF-b receptor ligand and regulates epithelial-mesenchymal transition in lung cancer. Oncogene 2011; 30(34):3682-93
  30. Ho BC, Yu SL, Chen JJW, Chang SY, Yan BS, Hong, QS, Singh S, Kao CL, Chen HY, Su KY, Li KC, Cheng CL, Cheng HW, Lee JY, Lee CN, Yang PC: Enterovirus-induced miR-141 contributes to shutoff of host protein translation by targeting the translation initiation factor eIF4E. Cell Host Microbe 2011;9(1):58-69
  31. Chang TH, Tsai MF, Su KY, Wu SG, Huang CP, Yu SL, Yu YL, Chou-Chin Lan CC,   Yang CH, Lin SB, Wu CP, Shih JY, Yang PC: Slug confers resistance to the epidermal growth factor receptor tyrosine kinase inhibitor. Am J Respir Crit Care Med 201;183(8):1071-9.  
  32. Yuan A, Shih CM, Lin CY, Chen CY, Cheng HW , Chen YF, Chen JJW, Chen JH, Yang PC, Chang C:  valuation of functional and structural characteristics of tumor angiogenesis in lung cancers overexpressing different VEGF isoforms by DCE and SSCE MR imaging.  PLoS One 2011 in press.
  33. Wu JY, Wu SG, Yang CH, Chang YL, Chang YC, Hsu YC, Shih JY, Yang PC:  Comparison of gefitinib and erlotinib in advanced NSCLC and the effect of EGFR mutations.  Lung Cancer 2010 Sep 8.
  34. Chen BZ, Yu SL, Singh S, Kao LP, Tsai ZY, Yang PC, Chen BH, Li SS:  Identification of microRNAs expressed highly in pancreatic islet-like cell clusters differentiated from human embryonic stem cells.  Cell Biol Int 2010 Aug 25.
  35. Wu JY, Yu CJ, Shih JY, Yang CH, Yang PC:  Influence of first-line chemotherapy and EGFR mutations on second-line gefitinib in advanced non-small cell lung cancer.  Lung Cancer 2010;67(3):348-54.
  36. Wang CY, Wang HC, Li JM, Wang JY, Yang KC, Ho YK, Lin PY, Lee LN, Yu CJ, Yang PC, Hsueh PR:  Invasive infections of aggregatibacter (actinobacillus) actinomycetemcomitans.  J Microbiol Immunol Infect. 2010;43(6):491-7.
  37. Shiao TH, Chang YL, Yu CJ, Chang YC, Hsu YC, Chang SH, Shih JY, Yang PC:   Epidermal growth factor receptor mutations in small cell lung cancer: a brief report.  J Thorac Oncol 2011;6(1):195-8.
  38. Kuo YW, Jerng JS, Shih JY, Chen KY, Yu CJ, Yang PC:  The prognostic value of the simplified comorbidity score in the treatment of small cell lung carcinoma.  J Thorac Oncol 2010 Dec 17.
  39. Wu SG, Yang CH, Yu CJ, Lee JH, Hsu YC, Chang YL, Shih JY, Yang PC:  Good response to pemetrexed in patients of lung adenocarcinoma with epidermal growth factor receptor (EGFR) mutations.  Lung Cancer 2010 Nov 24.
  40. Liao YC, Liao WY, Shun SC, Yu CJ, Yang PC, Lai YH:  Symptoms, psychological distress, and supportive care needs in lung cancer patients.  Support Care Cancer 2010 Oct 15.
  41. Hsu HL, Lai CC, Yu MC, Yu FL, Lee JC, Chou CH, Tan CK, Yang PC, Hsueh PR:  Clinical and microbiological characteristics of urine culture-confirmed genitourinary tuberculosis at medical centers in Taiwan from 1995 to 2007.  Eur J Clin Microbiol Infect Dis 2010 Oct 15.
  42. Wang JY, Hsu HL, Yu MC, Chiang CY, Yu FL, Yu CJ, Lee LN, Yang PC; the TAMI Group:  Mixed infection with Beijing and non-Beijing strains in pulmonary tuberculosis in Taiwan: prevalence, risk factors, and dominant strain.  Clin Microbiol Infect 2010 Oct 14.
  43. Wang CY, Hsiao YC, Jerng JS, Ho CC, Lai CC, Yu CJ, Hsueh PR, Yang PC:  Diagnostic value of procalcitonin in pleural effusions.  Eur J Clin Microbiol Infect Dis 2010 Oct 13.
  44. Lin PY, Yu SL, Yang PC:  MicroRNA in lung cancer.  Br J Cancer 2010 Oct 12;103(8):1144-8. Epub 2010 Sep 21. Review.
  45. Wang YT, Tsai CF, Hong TC, Tsou CC, Lin PY, Pan SH, Hong TM, Yang PC, Sung TY, Hsu WL, Chen YJ:  An informatics-assisted label-free quantitation strategy that depicts phosphoproteomic profiles in lung cancer cell invasion.  J Proteome Res 2010 Nov 5;9(11):5582-97.
  46. Lu TP, Tsai MH, Lee JM, Hsu CP, Chen PC, Lin CW, Shih JY, Yang PC, Hsiao CK, Lai LC, Chuang EY:  Identification of a novel biomarker, SEMA5A, for non-small cell lung carcinoma in nonsmoking women.  Cancer Epidemiol Biomarkers Prev 2010 Oct;19(10):2590-7.
  47. Wu JY, Yang CH, Hsu YC, Yu CJ, Chang SH, Shih JY, Yang PC:  Use of cetuximab after failure of gefitinib in patients with advanced non-small-cell lung cancer.  Clin Lung Cancer 2010 Jul 1;11(4):257-63.
  48. Liu WL, Kuo PH, Ku SC, Huang PM, Yang PC:  Impact of therapeutic interventions on survival of patients with hepatic hydrothorax.  J Formos Med Assoc 2010 Aug;109(8):582-8.
  49. Chen CY, Hsu CL, Chang CH, Chen KY, Yu CJ, Yang PC:   Hemothorax in a medical intensive care unit: incidence, comorbidity and prognostic factors.  J Formos Med Assoc 2010 Aug;109(8):574-81.
  50. Hsiung CA, Lan Q, Hong YC, Chen CJ, Hosgood HD, Chang IS, Chatterjee N, Brennan P, Wu C, Zheng W, Chang GC, Wu T, Park JY, Hsiao CF, Kim YH, Shen H, Seow A, Yeager M, Tsai YH, Kim YT, Chow WH, Guo H, Wang WC, Sung SW, Hu Z, Chen KY, Kim JH, Chen Y, Huang L, Lee KM, Lo YL, Gao YT, Kim JH, Liu L, Huang MS, Jung TH, Jin G, Caporaso N, Yu D, Kim CH, Su WC, Shu XO, Xu P, Kim IS, Chen YM, Ma H, Shen M, Cha SI, Tan W, Chang CH, Sung JS, Zhang M, Yang TY, Park KH, Yuenger J, Wang CL, Ryu JS, Xiang Y, Deng Q, Hutchinson A, Kim JS, Cai Q, Landi MT, Yu CJ, Park JY, Tucker M, Hung JY, Lin CC, Perng RP, Boffetta P, Chen CY, Chen KC, Yang SY, Hu CY, Chang CK, Fraumeni JF Jr, Chanock S, Yang PC, Rothman N, Lin D:  The 5p15.33 locus is associated with risk of lung adenocarcinoma in never-smoking females in Asia.  PLoS Genet 2010 Aug 5;6(8) pii: e1001051.
  51. Lo YL, Hsiao CF, Jou YS, Chang GC, Tsai YH, Su WC, Chen YM, Huang MS, Chen HL, Yang PC, Chen CJ, Hsiung CA:  ATM polymorphisms and risk of lung cancer among never smokers.  Lung Cancer 2010 Aug;69(2):148-54..
  52. Wu JY, Yang CH, Hsu YC, Yu CJ, Chang SH, Shih JY, Yang PC:  Use of cetuximab after failure of gefitinib in patients with advanced non-small-cell lung cancer.  Clin Lung Cancer 2010 Jul 1;11(4):257-63.
  53. Cheng SL, Wang HC, Yang PC, Kuo SH:  Risk factors for high mesothelial cell counts in HIV-negative patients with tuberculous pleural effusion.  J Formos Med Assoc 2010 Jun;109(6):456-62.
  54. Lin RK, Wu CY, Chang JW, Juan LJ, Hsu HS, Chen CY, Lu YY, Tang YA, Yang YC, Yang PC, Wang YC:  Dysregulation of p53/Sp1 control leads to DNA methyltransferase-1 overexpression in lung cancer.  Cancer Res 2010 Jul 15;70(14):5807-17. Epub 2010 Jun 22.
  55. Chien JY, Huang RM, Wang JY, Ruan SY, Chien YJ, Yu CJ, Yang PC:  Hepatitis C virus infection increases hepatitis risk during anti-tuberculosis treatment.  Int J Tuberc Lung Dis 2010 May;14(5):616-21.
  56. Chen WT, Thirumalai D, Shih TT, Chen RC, Tu SY, Lin CI, Yang PC:  Dynamic Contrast-Enhanced Folate-Receptor-Targeted MR Imaging Using a Gd-loaded PEG-Dendrimer-Folate Conjugate in a Mouse Xenograft Tumor Model.  Mol Imaging Biol 2010 Apr;12(2):145-54
  57. Lin PY, Chang YC, Chen HY, Chen CH, Tsui HC, Yang PC:  Tumor size matters differently in pulmonary adenocarcinoma and squamous cell carcinoma.  Lung Cancer 2010 Mar;67(3):296-300.
  58. Huang CT, Yen RF, Cheng MF, Hsu YC, Wei PF, Tsai YJ, Tsai MF, Shih JY, Yang CH, Yang PC:  Correlation of F-18 fluorodeoxyglucose-positron emission tomography maximal standardized uptake value and EGFR mutations in advanced lung adenocarcinoma.  Med Oncol 2010 Mar;27(1):9-15.
  59. Chang TP, Yu SL, Lin SY, Hsiao YJ, Chang GC, Yang PC, Chen JJ:  Tumor suppressor HLJ1 binds and functionally alters nucleophosmin via activating enhancer binding protein 2alpha complex formation.  Cancer Res 2010 Feb 15;70(4):1656-67. Epub 2010 Feb 9.
  60. Lai CC, Tan CK, Chou CH, Hsu HL, Liao CH, Huang YT, Yang PC, Luh KT, Hsueh PR:  Increasing incidence of nontuberculous mycobacteria, Taiwan, 2000-2008.  Emerg Infect Dis 2010 Feb;16(2):294-6.
  61. Tan EH, Ramlau R, Pluzanska A, Kuo HP, Reck M, Milanowski J, Au JS, Felip E, Yang PC, Damyanov D, Orlov S, Akimov M, Delmar P, Essioux L, Hillenbach C, Klughammer B, McLoughlin P, Baselga J:  A multicentre phase II gene expression profiling study of putative relationships between tumour biomarkers and clinical response with erlotinib in non-small-cell lung cancer.  Ann Oncol 2010 Feb;21(2):217-22.
  62. Chien MY, Wu YT, Lee PL, Chang YJ, Yang PC:  Inspiratory muscle dysfunction in patients with severe obstructive sleep apnoea.  Eur Respir J 2010 Feb;35(2):373-80.
  63. Shu CC, Wu HD, Yu MC, Wang JT, Lee CH, Wang HC, Wang JY, Lee LN, Yu CJ, Yang PC; Taiwan Anti-Mycobacteria Investigation (TAMI) Group:  Use of high-dose inhaled corticosteroids is associated with pulmonary tuberculosis in patients with chronic obstructive pulmonary disease.  Medicine (Baltimore) 2010;89:53-61.
  64. Lim CS, Lee CH, Chien YJ, Wang JY, Lee LN, Yu CJ, Yang PC; TAMI group:  Culture result of smear-positive sputum samples after 2 months of antituberculous treatment.  Eur Respir J 2010;35:218-20.
  65. Wang JY, Wang JT, Tsai TH, Hsu CL, Yu CJ, Hsueh PR, Lee LN, Yang PC:  Adding moxifloxacin is associated with a shorter time to culture conversion in pulmonary tuberculosis.  Int J Tuberc Lung Dis 2010;14:65-71.
  66. Chen KY, Chen JH, Shih JY, Yang CH, Yu CJ, Yang PC:  Octogenarians with advanced non-small cell lung cancer: treatment modalities, survival, and prognostic factors.  J Thorac Oncol 2010;5:82-9.
  67. Pan SH, Chao YC, Chen HY, Hung PF, Lin PY, Lin CW, Chang YL, Wu CT, Lee YC, Yang SC, Hong TM, Yang PC:  Long form collapsin response mediator protein-1 (LCRMP-1) expression is associated with clinical outcome and lymph node metastasis in non-small cell lung cancer patients.  Lung Cancer 2010;67:93-100.
  68. Wu JY, Shih JY, Yang CH, Chen KY, Ho CC, Yu CJ, Yang PC:  Second-line treatments after first-line gefitinib therapy in advanced nonsmall cell lung cancer.  Int J Cancer 2010;126:247-55.
  69. Chu DW, Hwang SJ, Lim FS, Oh HM, Thongcharoen P, Yang PC, Bock HL, Dramé M, Gillard P, Hutagalung Y, Tang H, Teoh YL, Ballou RW; H5N1 Flu Study Group for Hong Kong, Singapore, Taiwan and Thailand:  Immunogenicity and tolerability of an AS03(A)-adjuvanted prepandemic influenza vaccine: a phase III study in a large population of Asian adults.  Vaccine 2009;27:7428-35.
  70. Hsu YC, Yuan S, Chen HY, Yu SL, Liu CH, Hsu PY, Wu G, Lin CH, Chang GC, Li KC, Yang PC:  A four-gene signature from NCI-60 cell line for survival prediction in non-small cell lung cancer.  Clin Cancer Res 2009;15:7309-15.
  71. Cheng SL, Wang HC, Yu CJ, Tsao PN, Carmeliet P, Cheng SJ, Yang PC:  Prevention of elastase-induced emphysema in placenta growth factor knock-out mice.  Respir Res 2009;10:115.
  72. Chu TS, Weed HG, Yang PC:  Recommendations for medical education in Taiwan.  J Formos Med Assoc 2009;108:830-3.
  73. Chen TC, Lee SA, Hong TM, Shih JY, Lai JM, Chiou HY, Yang SC, Chan CH, Kao CY, Yang PC, Huang CY:  From midbody protein-protein interaction network construction to novel regulators in cytokinesis.  J Proteome Res 2009;8:4943-53.
  74. Lin SH, Kuo PH, Kuo SH, Yang PC:  Severity staging of chronic obstructive pulmonary disease: differences in pre- and post-bronchodilator spirometry.  Yonsei Med J 2009;50:672-6.
  75. Chen CY, Yang KY, Chen MY, Chen HY, Lin MT, Lee YC, Perng RP, Hsieh SL, Yang PC, Chou TY:  Decoy receptor 3 levels in peripheral blood predict outcomes of acute respiratory distress syndrome.  Am J Respir Crit Care Med 2009;180:751-60.
  76. Huang CT, Tsai YJ, Shu CC, Lei YC, Wang JY, Yu CJ, Lee LN, Yang PC; Tami Group:  Clinical significance of isolation of nontuberculous mycobacteria in pulmonary tuberculosis patients.  Respir Med 2009;103:1484-91.
  77. Lin PY, Wang JY, Hsueh PR, Lee LN, Hsiao CH, Yu CJ, Yang PC:  Lower gastrointestinal tract tuberculosis: an important but neglected disease.  Int J Colorectal Dis 2009;24:1175-80.
  78. Chang CH, Hsiao CF, Chang GC, Tsai YH, Chen YM, Huang MS, Su WC, Hsieh WS, Yang PC, Chen CJ, Hsiung CA:  Interactive effect of cigarette smoking with human 8-oxoguanine DNA N-glycosylase 1 (hOGG1) polymorphisms on the risk of lung cancer: a case-control study in Taiwan.  Am J Epidemiol 2009;170:695-702.
  79. Wang JY, Lee LN, Yu CJ, Chien YJ, Yang PC; Tami Group:  Factors influencing time to smear conversion in patients with smear-positive pulmonary tuberculosis.  Respirology 2009;14:1012-9.
  80. Huang CT, Ho CC, Tsai YJ, Yu CJ, Yang PC:  Factors influencing visibility and diagnostic yield of transbronchial biopsy using endobronchial ultrasound in peripheral pulmonary lesions.  Respirology 2009;14:859-64.
  81. Cheng SL, Yu CJ, Yang PC:  Genetic polymorphisms of cytochrome p450 and matrix metalloproteinase in chronic obstructive pulmonary disease.  Biochem Genet 2009;47:591-601.
  82. Wu SG, Kuo PH, Yang PC:  Successful weaning after plasma exchange for polyneuropathy related to POEMS syndrome.  J Clin Apher 2009;24:170-2.
  83. Wang SP, Wang WL, Chang YL, Wu CT, Chao YC, Kao SH, Yuan A, Lin CW, Yang SC, Chan WK, Li KC, Hong TM, Yang PC:  p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug.  Nat Cell Biol 2009;11:694-704.
  84. Lin MT, Wang JY, Yu CJ, Lee LN, Yang PC; TAMI Group:  Mycobacterium tuberculosis and polymorphonuclear pleural effusion: incidence and clinical pointers.  Respir Med 2009;103:820-6.
  85. Huang CL, Yang CH, Yeh KH, Hu FC, Chen KY, Shih JY, Lin ZZ, Yu CJ, Cheng AL, Yang PC:  EGFR intron 1 dinucleotide repeat polymorphism is associated with the occurrence of skin rash with gefitinib treatment.  Lung Cancer 2009;64:346-51.
  86. Jou YS, Lo YL, Hsiao CF, Chang GC, Tsai YH, Su WC, Chen YM, Huang MS, Chen HL, Chen CJ, Yang PC, Hsiung CA:  Association of an EGFR intron 1 SNP with never-smoking female lung adenocarcinoma patients.  Lung Cancer 2009;64:251-6.
  87. Ho CC, Chen YC, Hu FC, Yu CJ, Yang PC, Luh KT:  Safety of fluoroquinolone use in patients with hepatotoxicity induced by anti-tuberculosis regimens.  Clin Infect Dis 2009;48:1526-33.
  88. Lin JC, Yang SC, Hong TM, Yu SL, Shi Q, Wei L, Chen HY, Yang PC, Lee KH:  Phenanthrene-based tylophorine-1 (PBT-1) inhibits lung cancer cell growth through the Akt and NF-kappaB pathways.  J Med Chem. 2009;52:1903-11.
  89. Gow CH, Chang YL, Hsu YC, Tsai MF, Wu CT, Yu CJ, Yang CH, Lee YC, Yang PC, Shih JY:  Comparison of epidermal growth factor receptor mutations between primary and corresponding metastatic tumors in tyrosine kinase inhibitor-naive non-small-cell lung cancer.  Ann Oncol 2009;20:696-702.
  90. Li SS, Yu SL, Kao LP, Tsai ZY, Singh S, Chen BZ, Ho BC, Liu YH, Yang PC:  Target identification of microRNAs expressed highly in human embryonic stem cells.  J Cell Biochem 2009;106:1020-30.
  91. Shih TTF, Hou HA, Liu CY, Chen BB, Tang JL, Chen HY, Wei SY, Yao M, Huang SY, Chou WC, Hsu SC, Tsay W, Yu CW, Hsu CY, Tien HF, Yang PC: Bone marrow angiogenesis magnetic resonance imaging in patients with acute myeloid leukemia: peak enhancement ratio is an independent predictor for overall survival.  Blood 2009;113:3161-7.
  92. Chien JY, Hsueh PR, Yu CJ, Yang PC:  The evolution of drug-resistant microorganisms in patients with prolonged mechanical ventilation.  Am J Infect Control 2009;37:231-6.
  93. Tjiu JW, Chen JS, Shun CT, Lin SJ, Liao YH, Chu CY, Tsai TF, Chiu HC, Dai YS, Inoue H, Yang PC, Kuo ML, Jee SH:  Tumor-associated macrophage-induced invasion and angiogenesis of human basal cell carcinoma cells by cyclooxygenase-2 induction.  J Invest Dermatol 2009;129:1016-25.
  94. Hsu CL, Chang CH, Wong KN, Chen KY, Yu CJ, Yang PC:  Management of severe community-acquired septic meningitis in adults: from emergency department to intensive care unit.  J Formos Med Assoc 2009;108:112-8.
  95. Wu JY, Wu SG, Sun HY, Kuo PH, Yang PC:  Critical illness polyneuromyopathy in a patient with disseminated cryptococcal infection.  J Hosp Med 2009;4:E3-6.
  96. Lee P, Su YN, Yu CJ, Yang PC, Wu HD:  PHOX2B mutation-confirmed congenital central hypoventilation syndrome in a Chinese family: presentation from newborn to adulthood.  Chest 2009;135:537-44.
  97. Lee LN, Chou CH, Wang JY, Hsu HL, Tsai TH, Jan IS, Hsueh PR, Yang PC:  Enzyme-linked immunospot assay for interferon-gamma in the diagnosis of tuberculous pleurisy.  Clin Microbiol Infect 2009;15:173-9.
  98. Ruan SY, Chen KY, Yang PC:  Recurrent respiratory papillomatosis with pulmonary involvement: a case report and review of the literature.  Respirology 2009;14:137-40. (Review)
  99. Chao YC, Pan SH, Yang SC, Yu SL, Che TF, Lin CW, Tsai MS, Chang GC, Wu CH, Wu YY, Lee YC, Hong TM, Yang PC:  Claudin-1 is a Metastasis Suppressor and Correlates with Clinical Outcome in Lung Adenocarcinoma.  Am J Respir Crit Care Med 2009;179:123-33.
  100. Wu JY, Kuo PH, Fan PC, Wu HD, Shih FY, Yang PC:  The role of non-invasive ventilation and factors predicting extubation outcome in myasthenic crisis.  Neurocrit Care 2009;10:35-42.
  101. Shu CC, Lee CH, Wang JY, Jerng JS, Yu CJ, Hsueh PR, Lee LN, Yang PC; the TAMI group:  Non-tuberculous mycobacteria pulmonary infection in medical intensive care unit: the incidence, patient characteristics, and clinical significance.  Intensive Care Med 2008;34:2194-201.
  102. Huang CT, Kuo PH, Yao M, Tsai YJ, Yang PC:  Pleural effusion heralds acute leukemic transformation of chronic myelomonocytic leukemia.  South Med J 2008;101:1279-80.
  103. Wu SG, Chang YL, Hsu YC, Wu JY, Yang CH, Yu CJ, Tsai MF, Shih JY, Yang PC:  Good response to gefitinib in lung adenocarcinoma of complex epidermal growth factor receptor (EGFR) mutations with the classical mutation pattern.  Oncologist 2008;13:1276-84.
  104. Lin PY, Kuo PH, Yu CJ, Yang PC:  Long-term remission of hepatic hydrothorax after OK-432 pleurodesis.  J Thorac Cardiovasc Surg 2008;136:1367-9.
  105. Hsu C, Kuo SH, Hu FC, Cheng AL, Shih JY, Yu CJ, Lin CC, Huang TC, Yang PC, Yang CH:  Gemcitabine plus conventional-dose epirubicin versus gemcitabine plus cisplatin as first-line chemotherapy for stage IIIB/IV non-small cell lung carcinoma-A randomized phase II trial.  Lung Cancer 2008;62:334-43.
  106. Chang CH, Chen KY, Young-Xu Y, Kurth T, Orav EJ, Yang PC, Chan KA:  The safety and efficacy of gefitinib versus platinum-based doublets chemotherapy as the first-line treatment for advanced non-small-cell lung cancer patients in East Asia: a meta-analysis.  Lung Cancer 2008;62:242-52.
  107. Lin MT, Shih JY, Lee YC, Yang PC:  Pleurocutaneous fistula after tube thoracostomy: sonographic findings.  J Clin Ultrasound 2008;36:523-5.
  108. Lee CY, Sher HF, Chen HW, Liu CC, Chen CH, Lin CS, Yang PC, Tsay HS, Chen JJ:  Anticancer effects of tanshinone I in human non-small cell lung cancer.  Mol Cancer Ther 2008;7:3527-38.
  109. Liu WL, Wang HC, Luh KT, Yang PC:  Recurrent bilateral pneumothoraces: a rare complication of miliary tuberculosis.  J Formos Med Assoc 2008;107:902-6.
  110. Chuang TY, Yu CJ, Shih JY, Yang PC, Kuo SH:  Cytologically proven meningeal carcinomatosis in patients with lung cancer: clinical observation of 34 cases.  J Formos Med Assoc 2008;107:851-6.
  111. Lin PY, Yu CJ, Yao M, Ku SC, Lee LN, Yang PC:  A patient with bronchiectasis presented with progressive dyspnoea and an unresolved right lower lung infiltrate.  Thorax 2008;63:876.
  112. Wu JY, Yu CJ, Yang CH, Wu SG, Chiu YH, Gow CH, Chang YC, Hsu YC, Wei PF, Shih JY, Yang PC:  First- or second-line therapy with gefitinib produces equal survival in non-small cell lung cancer.  Am J Respir Crit Care Med 2008 ;178:847-53.
  113. Lai CC, Tan CK, Huang YT, Chou CH, Hung CC, Yang PC, Luh KT, Hsueh PR:  Extensively drug-resistant Mycobacterium tuberculosis during a trend of decreasing drug resistance from 2000 through 2006 at a Medical Center in Taiwan.  Clin Infect Dis 2008;47:e57-63.
  114. Wu SG, Gow CH, Yu CJ, Chang YL, Yang CH, Hsu YC, Shih JY, Lee YC, Yang PC:  Frequent epidermal growth factor receptor gene mutations in malignant pleural effusion of lung adenocarcinoma.  Eur Respir J 2008;32:924-30.
  115. Chen HW, Lee JY, Huang JY, Wang CC , Chen WJ, Su SF, Huang CW, Ho CC, Tsai MF, Yu SL, Chen JJW, Yang PC:  Curcumin Inhibits Lung Cancer Cell Invasion and Metastasis through the Tumor Suppressor HLJ1.  Cancer Research 2008; 68:7428-38.
  116. Wu JY, Wu SG, Yang CH, Gow CH, Chang YL, Yu CJ, Shih JY, Yang PC:   Lung cancer with epidermal growth factor receptor exon 20 mutations is associated with poor gefitinib treatment response.  Clin Cancer Res 2008;14:4877-82.
  117. Chen HI, Hsu FH, Jiang Y, Tsai MH, Yang PC, Meltzer PS, Chuang EY, Chen Y:  A probe-density-based analysis method for array CGH data: simulation, normalization and centralization.  Bioinformatics 2008;24:1749-56.
  118. Wu CC, Lin JC, Yang SC, Lin CW, Chen JJW, Shih JY, Hong TM, Yang PC:  Modulation of the expression of the invasion-suppressor CRMP-1 by COX-2 inhibition via reciprocal regulation of Sp1 and C/EBPa.  Mol Cancer Ther 2008;7:1365-75.   
  119. Yang CH, Yu CJ, Shih JY, Chang YC, Hu FC, Tsai MC, Chen KY, Lin ZZ, Huang CH, Shun CT, Huang CL, Bean J, Cheng AL, Pao W, Yang PC:  Specific EGFR mutations predict treatment outcome of stage III/IV chemonaive NSCLC patients receiving first-line gefitinib monotherapy.  J Clin Oncol 2008;26:2745-53.
  120. Wu JY, Hsu SC, Ku SC, Ho CC, Yu CJ, Yang PC:  Adrenal insufficiency in prolonged critical illness.  Crit Care 2008;12:R65.
  121. Lin ZZ, Hsu C, Chang YC, Yu CJ, Hsu CH, Lin CC, Cheng AL, Yang PC, Yang CH:  Outcome of advanced nonsmall cell lung cancer patients receiving gemcitabine and weekly paclitaxel as first-line treatment.  Lung Cancer 2008;60:215-21.
  122. Chien JY, Lin MS, Huang YC, Chien YF, Yu CJ, Yang PC:  Changes in B-type natriuretic peptide improve weaning outcome predicted by spontaneous breathing trial.  Crit Care Med 2008;36:1421-6.
  123. Lin PY, Shih JY, Wu MZ, Chang YT, Yang PC:  Extensive GI tract involvement of Ewing's sarcoma/peripheral primitive neuroectodermal tumor in an octogenarian.  Gastrointest Endosc 2008;67:1196-8.
  124. Cheng SL, Wang HC, Yu CJ, Yang PC:  Increased expression of placenta growth factor in COPD.  Thorax 2008;63:500-6.
  125. Wu SG, Shih JY, Yu CJ, Yang PC:  Lung adenocarcinoma with good response to erlotinib after gefitinib treatment failure and acquired T790M mutation.  J Thorac Oncol 2008;3:451-2.
  126. Wei YF, Liaw YS, Ku SC, Chang YL, Yang PC:  Clinical features and predictors of a complicated treatment course in peripheral tuberculous lymphadenitis.  J Formos Med Assoc 2008;107:225-31.
  127. Chuang YM, Ho YC, Chang HT, Yu CJ, Yang PC, Hsueh PR:  Disseminated cryptococcosis in HIV-uninfected patients.  Eur J Clin Microbiol Infect Dis 2008;27:307-10.
  128. Ho CC, Liao WY, Wang CY, Lu YH, Huang HY, Chen HY, Chan WK, Chen HW, Yang PC:  TREM-1 expression in tumor-associated macrophages and clinical outcome in lung cancer.  Am J Respir Crit Care Med 2008;177:763-70.  
  129. Huang CT, Ho CC, Tsai YJ, Yang PC:  The first case report of dental floss pick-related injury presenting with massive hemoptysis: A case report.  J Med Case Reports 2008;2:78.
  130. Lin PY, Chen JS, Ku SC, Wu MZ, Yu CJ, Yang PC:  A 50-year-old man with bilateral pulmonary tumours.  Thorax 2008;63:193.
  131. Chou CC, Hsiao HY, Hong QS, Chen CH, Peng YW, Chen HW, Yang PC:  Single-Walled Carbon Nanotubes Can Induce Pulmonary Injury in Mouse Model.   Nano Lett 2008;8:437-445.
  132. Yuan A, Chen JJ, Yang PC:  Pathophysiology of tumor-associated macrophages.  Adv Clin Chem 2008;45:199-223.
  133. Ho CC, Kuo SH, Huang PH, Huang HY, Yang CH, Yang PC:  Caveolin-1 expression is significantly associated with drug resistance and poor prognosis in advanced non-small cell lung cancer patients treated with gemcitabine-based chemotherapy.  Lung Cancer 2008;59:105-110.
  134. Chang YC, Yu CJ, Lee WJ, Kuo SH, Hsiao CH, Jan IS, Hu FC, Liu HM, Chan WK, Yang PC:  Imprint cytology improves accuracy of CT-guided percutaneous transthoracic needle biopsy.  Eur Respir J 2008;31:54-61.
  135. Huang CT, Huang WC, Shih JY, Yang PC:  Primary mediastinal large B-cell lymphoma mimicking liposarcoma.  Med Oncol 2008;25:284-6.
  136. Yu SL, Chen HY, Chang GC, Chen CY, Chen HW, Singh S, Cheng CL, Yu CJ, Lee YC, Chen HS, Su TJ, Chiang CC, Li HN, Hong QS, Su HY, Chen CC, Chen WJ, Liu CC, Chan WK, Chen WJ, Li KC, Chen JJW, Yang PC:  MicroRNA signature predicts survival and relapse in lung cancer.  Cancer Cell 2008;13:1-10.
  137. Gow CH, Chien CR, Chang YL, Chiu YH, Kuo SH, Shih JY, Chang YC, Yu CJ, Yang CH, Yang PC:  Radiotherapy in lung adenocarcinoma with brain metastases: effects of activating epidermal growth factor receptor mutations on clinical response.  Clin Cancer Res 2008;14:162-8.
  138. Bean J, Brennan C, Shih JY, Riely G, Viale A, Wang L, Chitale D, Motoi N, Szoke J, Broderick S, Balak M, Chang WC, Yu CJ, Gazdar A, Pass H, Rusch V, Gerald W, Huang SF, Yang PC, Miller V, Ladanyi M, Yang CH, Pao W:  MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib.  Proc Natl Acad Sci U S A 2007;104:20932-7.
  139. Cheng SL, Wang HC, Yang PC:  Paradoxical response during anti-tuberculosis treatment in HIV-negative patients with pulmonary tuberculosis.  Int J Tuberc Lung Dis 2007;11:1290-5.
  140. Wang JY, Lee LN, Lai HC, Hsu HL, Jan IS, Yu CJ, Hsueh PR, Yang PC:  Performance assessment of the Capilia TB assay and the BD ProbeTec ET system for rapid culture confirmation of Mycobacterium tuberculosis.  Diagn Microbiol Infect Dis 2007;59:395-9.
  141. Luh SP, Kuo PH, Kuo TF, Tsai TP, Tsao TC, Chen JY, Tsai CH, Yang PC:  Effects of thermal preconditioning on the ischemia-reperfusion-induced acute lung injury in minipigs.  Shock 2007; 28:615-22.
  142. Chen KY, Hsiao CF, Chang GC, Tsai YH, Su WC, Perng RP, Huang MS, Hsiung C, Chen CJ, Yang PC, and the GEFLAC Study Group:  Hormone replacement therapy and lung cancer risk in Chinese.  Cancer 2007;110:1768-75.
  143. Hong TM, Chen YL, Wu YY, Yuan A, Chao YC, Chung YC, Wu MH, Yang SC, Pan SH, Shih JY, Chan WK, Yang PC:  Targeting neuropilin 1 as an antitumor strategy in lung cancer.  Clin Cancer Res 2007;13:4759-68.
  144. Wang JY, Lee LN, Lai HC, Hsu HL, Liaw YS, Hsueh PR, Yang PC:  Prediction of the tuberculosis reinfection proportion from the local incidence.  J Infect Dis 2007;196:281-8.
  145. Tai KY, Shiah SG, Shieh YS, Kao YR, Chi CY, Huang E, Lee HS, Chang LC, Yang PC, Wu CW:  DNA methylation and histone modification regulate silencing of epithelial cell adhesion molecule for tumor invasion and progression.  Oncogene 2007;26:3989-97.
  146. Jerng JS, Hsu YC, Wu HD, Pan HZ, Wang HC, Shun CT, Yu CJ, Yang PC:  Role of the rennin-angiotensin system in ventilator-induced lung injury: An in vivo study in a rat model.  Thorax 2007;62:527-35.  
  147. Lin YF, Chen CY, Tsai MH, Wu MS, Wang YC, Chuang EY., Lin JT, Yang PC, Chow LP: Duodenal ulcer-related antigens from Helicobacter pylori: immunoproteome and protein microarray approaches.  Mol Cell Proteomics 2007;6:1018-26.
  148. Liu CC, Lin CC, Li KC, Chen WS, Chen JC, Yang MT, Yang PC, Chang PC, Chen JJW:  Genome-wide identification of specific oligonucleotides using artificial neural network and computational genomic analysis.  BMC Bioinformatics. 2007;8:164.
  149. Wang CC, Tsai MF, Dai TH, Hong TM, Chan WK, Chen JJW, Yang PC:  Synergistic activation of the tumor suppressor, HLJ1, by the transcription factors YY1 and activator protein 1.  Cancer Res 2007;67:4816-26.  
  150. Wang JY, Lee LN, Lai HC, Wang SK, Jan IS, Yu CJ, Hsueh PR, Yang PC:  Fluoroquinolone resistance in Mycobacterium tuberculosis isolates: associated genetic mutations and relationship to antimicrobial exposure.  J Antimicrob Chemother 2007;59:860-5.
  151. Yu SL, Chen HY, Yang PC, Chen JJW:  Unique MicroRNA signature and clinical outcome of cancers.  DNA Cell Biol 2007;26:283-92.
  152. Wang JY, Chou CH, Lee LN, Hsu HL, Jan IS, Hsueh PR, Yang PC, Luh KT:   Diagnosis of tuberculosis by an enzyme-linked immunospot assay for interferon-gamma.  Emerg Infect Dis 2007;13:553-8.
  153. Chen YM, Yu CJ, Yang CH, Perng RP, Tsai CM, Shih JF, Cheng AL, Lefresne F, Barbier M, Pouget JC, Yang PC:  A phase II study of oral vinorelbine in combination with cisplatin conducted in Taiwan in patients with unresectable localized or metastatic non-small cell lung carcinoma.  Lung Cancer 2007;56:89-95.
  154. Lai CC, Lee LN, Yu CJ, Hsueh PR, Yang PC, Kuo SH, Luh KT:  Antibody responses to pneumococcal polysaccharide vaccine in Taiwanese patients with chronic obstructive pulmonary disease.  J Formos Med Assoc. 2007;106:196-203.
  155. Chen KY, Lee YC, Lai JM, Chang YL, Lee YC, Yu CJ, Huang CY, Yang PC:  Identification of trophinin as an enhancer for cell invasion and a prognostic factor for early stage lung cancer.  Eur J Cancer 2007;43:782-90.
  156. Su KY, Chien WL, Fu WM, Yu IS, Huang HP, Huang PH, Lin SR, Shih JY, Lin YL, Hsueh YP, Yang PC, Lin SW:  Mice deficient in collapsin response mediator protein-1 exhibit impaired LTP and impaired spatial learning and memory.  J Neurosci 2007;27:2513-24. (Share correspondence)
  157. Chen YS, Cheng SL, Wang HC, Yang PC:  Successful treatment of pulmonary hemorrhage associated with leptospirosis and scrub typhus co-infection by early plasma exchange.  J Formos Med Assoc 2007;106(2 Suppl):S1-6.
  158. Wang JY, Hsueh PR, Jan IS, Lee LN, Liaw YS, Yang PC, Luh KT:  The effect of smoking on tuberculosis: different patterns and poorer outcomes.  Int J Tuberc Lung Dis 2007;11:143-9.
  159. Wang JY, Hsueh PR, Wang SK, Jan IS, Lee LN, Liaw YS, Yang PC, Luh KT:  Disseminated tuberculosis: a 10-year experience in a medical center.  Medicine (Baltimore) 2007;86:39-46.
  160. Chang YC, Chang YL, Chen SY, Wang TC, Yang PC, Liu HM, Lee YC:  Intrapulmonary bronchogenic cysts: computed tomography, clinical and histopathologic correlations.  J Formos Med Assoc 2007;106:8-15.
  161. Chen HY, Yu SL, Chen CH, Chang GC, Chen CY, Yuan A; Cheng CL, Wang CH, Terng HJ, Kao SF, Chan WK, Li HN, Liu CC, Singh S, Chen WJ, Chen JJW, Yang PC:  A five-gene signature and clinical outcome in non–small cell lung cancer.  N Engl J Med 2007;356:11-20.
  162. Lin SH, Kuo PH, Hsueh PR, Yang PC, Kuo SH:  Sputum bacteriology in hospitalized patients with acute exacerbation of chronic obstructive pulmonary disease in Taiwan with an emphasis on Klebsiella pneumoniae and Pseudomonas aeruginosa.  Respirology 2007;12:81-7.
  1. US patent No. :5,789,173, Aug. 4, 1998.  Peck K, Yang PC, Wang SL:
    Methods for rapid antimicrobial susceptibility testing.
  2. US patent No.: 6,218,114 B1, April 17, 2001 (2001-2018).  Peck K, Chen JJW, Yang PC, et al.:  Methods for detecting differentially expressed genes.
  3. NZ patent No.: 519788, ZA patent No. 2002/4907, USA: Pending; 2003-2023.  Yang PC, Shih JY, Chen JJW, et al.: Collapsin response mediator protein-1.
  4. NZ patent No. :519789, USA: Pending; 2004-2024.  Chen JJW, Yang PC, Peck K, et al.: Metastasis-Associated Genes.
  5. US patent No.: 7,211,660 B2, May 1, 2007 (February 7, 2005~2025).  Yang PC, Hong TM, Chen JJW, Wu CC, Shih JY, Lee YJ:  Collapsin response mediator protein-1 (CRMP-1) transcriptional regulatory nucleic acid sequences.
  6. US patent No.: US 7,354,709 B2, April 8, 2008.  Yang PC, Shih JY, Chen JJW, Peck K, Wu CW, Hong TM, Yang SC:  Collapsin response mediator protein-1.
  7. US patent No.: US 7,507,534 B2, March 24, 2009.  Peck K, Sher YP, Shih JY, Yang PC, Wu CW:  Rapid efficacy assessment method for lung cancer therapy.