Professor Min-Liang Kao

  1. Cancer Biology
  2. Cellular and Molecular Biology
  3. Signal transduction
  4. Molecular Toxicology
Current Position:
  • Director General, Department of Life Sciences, National Science Council
  • Professor, Graduate Institute of Toxicology, National Taiwan University College of Medicine
  • B.S., Department of Nutritional Science, Fu Jen Catholic University
  • M.S., Graduate Institute of Biochemistry and Molecular Biology, National Taiwan University College of Medicine
  • Ph.D., Graduate Institute of Biochemistry and Molecular Biology, National Taiwan University College of Medicine
Tel: 886-2-23123456 #88607
Fax: 886-2-23410217
Selected Publications:
  1. Wu MH, Wang MY, Yang CY, Kuo ML, Lin MT. Randomized Clinical Trial of New Intravenous Lipid (SMOFlipid(R) 20%) Versus MCT/LCT in Adult Patients Undergoing Gastrointestinal Surgery. JPEN J Parenter Enteral Nutr. 2013; [Epub ahead of print]
  2. Hua KT, Lee WJ, Chen CK, Hsiao M, Ku CC, Wei LH, Kuo ML, Chien MH. Vascular endothelial growth factor-C modulates proliferation and chemoresistance in acute myeloid leukemic cells through an endothelin-1-dependent induction of cyclooxygenase-2. Biochim Biophys Acta. 2013; doi:pii: S0167-4889(13) 00360-1. 10.1016/j.bbamcr.2013.10.015. [Epub ahead of print]
  3. Chen CK, Yang CY, Hua KT, Ho MC, Johansson G, Jeng YM, Chen CN, Chen MW, Lee WJ, Su JL, Lai TC, Chou CC, Ho BC, Chang CF, Lee PH, Chang KJ, Hsiao M, Lin MT, Kuo ML*. Leukocyte Cell-derived chemotaxin 2 antagonizes MET receptor activation to suppress hepatocellular carcinoma vascular invasion by protein tyrosine phosphatase 1B recruitment. Hepatology. 2013; doi: 10.1002/hep.26738. [Epub ahead of print]
  4. Yang SJ, Lin CF, Kuo ML, Tan CT. Photodynamic detection of oral cancers with high-performance chitosan-based nanoparticles. Biomacromolecules. 2013; 14(9): 3183-91.
  5. Chien MH, Lee LM, Hsiao M, Wei LH, Chen CH, Lai TC, Hua KT, Chen MW, Sun CM, Kuo ML. Inhibition of Metastatic Potential in Breast Carcinoma In Vivo and In Vitro through Targeting VEGFRs and FGFRs. Evid Based Complement Alternat Med. 2013; 2013:718380.
  6. Chu CY, Sheen YS, Cha ST, Hu YF, Tan CT, Chiu HC, Chang CC, Chen MW, Kuo ML, Jee SH. Induction of chemokine receptor CXCR4 expression by transforming growth factor-β1 in human basal cell carcinoma cells. J Dermatol Sci. 2013; 72(2): 123-33.
  7. Chou CH, Lai SL, Chen CN, Lee PH, Peng FC, Kuo ML, Lai HS. IL-6 regulates Mcl-1L expression through the JAK/PI3K/Akt/CREB signaling pathway in hepatocytes: implication of an anti-apoptotic role during liver regeneration. PLoS One. 2013; 8(6): e66268.
  8. Chang CC, Hsu WH, Wang CC, Chou CH, Kuo MY, Lin BR, Chen ST, Tai SK, Kuo ML, Yang MH. Connective tissue growth factor activates pluripotency genes and mesenchymal-epithelial transition in head and neck cancer cells. Cancer Res. 2013; 73(13): 4147-57.
  9. Lai CF, Chen YM, Chiang WC, Lin SL, Kuo ML, Tsai TJ. Cysteine-rich protein 61 plays a proinflammatory role in obstructive kidney fibrosis. PLoS One. 2013; 8(2): e56481.
  10. Kuo TC, Tan CT, Chang YW, Hong CC, Lee WJ, Chen MW, Jeng YM, Chiou J, Yu P, Chen PS, Wang MY, Hsiao M, Su JL, Kuo ML*. Angiopoietin-like protein 1 suppresses SLUG to inhibit cancer cell motility. J Clin Invest. 2013; 123(3): 1082-95.
  11. Wei LH, Chou CH, Chen MW, Rose-John S, Kuo ML, Chen SU, Yang YS. The role of IL-6 trans-signaling in vascular leakage: implications for ovarian hyperstimulation syndrome in a murine model. J Clin Endocrinol Metab. 2013; 98(3): E472-84.
  12. Bai KJ, Chen BC, Pai HC, Weng CM, Yu CC, Hsu MJ, Yu MC, Ma HP, Wu CH, Hong CY, Kuo ML, Lin CH. Thrombin-induced CCN2 expression in human lung fibroblasts requires the c-Src/JAK2/STAT3 pathway. J Leukoc Biol. 2013; 93(1): 101-12.
  13. Chen PS, Su JL, Cha ST, Tarn WY, Wang MY, Hsu HC, Lin MT, Chu CY, Hua KT, Chen CN, Kuo TC, Chang KJ, Hsiao M, Chang YW, Chen JS, Yang PC, Kuo ML*. miR-107 promotes tumor progression by targeting the let-7 microRNA in mice and humans. J Clin Invest. 2011 Sep 1;121(9):3442-55. (Impact Factor:14.152)
  14. Pan SH, Chao YC, Hung PF, Chen HY, Yang SC, Chang YL, Wu CT, Chang CC, Wang WL, Chan WK, Wu YY, Che TF, Wang LK, Lin CY, Lee YC, Kuo ML, Lee CH, Chen JJ, Hong TM, Yang PC. The ability of LCRMP-1 to promote cancer invasion by enhancing filopodia formation is antagonized by CRMP-1. J Clin Invest. 2011 Aug 1;121(8):3189-205. (Impact Factor:14.152)
  15. Chen SC, Shih CM, Tseng GC, Cheng WE, Chiou J, Hsiao M, Kuo ML, Su JL, Chen CY. Vascular Endothelial Growth Factor C as a Predictor of Early Recurrence and Poor Prognosis of Resected Stage I Non-small Cell Lung Cancer. Ann Acad Med Singapore. 2011 Jul;40(7):319-6. (Impact Factor:1.203)
  16. Tseng PC, Hou SM, Chen RJ, Peng HW, Hsieh CF, Kuo ML, Yen ML. Resveratrol promotes osteogenesis of human mesenchymal stem cells by up-regulating RUNX2 gene expression via SIRT1/FOXO3A axis. J Bone Miner Res. 2011 Jun 28. doi: 10.1002/jbmr.460. (Impact Factor:7.056)
  17. Lin BR, Chang CC, Chen RJ, Jeng YM, Liang JT, Lee PH, Chang KJ, Kuo ML*. Connective tissue growth factor acts as a therapeutic agent and predictor for peritoneal carcinomatosis of colorectal cancer. Clin Cancer Res. 2011 May 15;17(10):3077-88. (Impact Factor:8.234)
  18. Yen ML, Hou CH, Peng KY, Tseng PC, Jiang SS, Shun CT, Chen YC, Kuo ML*. Efficient Derivation & Concise Gene Expression Profiling of Human Embryonic Stem Cell-Derived Mesenchymal Progenitors (EMPs). Cell Transplant. 2011 Mar 7. doi: 10.3727/096368910X564067. (Impact Factor:6.204)
  19. Hua KT, Tan CT, Johansson G, Lee JM, Yang PW, Lu HY, Chen CK, Su JL, Chen PB, Wu YL, Chi CC, Kao HJ, Shih HJ, Chen MW, Chien MH, Chen PS, Lee WJ, Cheng TY, Rosenberger G, Chai CY, Yang CJ, Huang MS, Lai TC, Chou TY, Hsiao M, Kuo ML*. N-α-acetyltransferase 10 protein suppresses cancer cell metastasis by binding PIX proteins and inhibiting Cdc42/Rac1 activity. Cancer Cell. 2011 Feb 15;19(2):218-31. (Impact Factor:26.925)
  20. Lo CW, Chen MW, Hsiao M, Wang S, Chen CA, Hsiao SM, Chang JS, Lai TC, Rose-John S, Kuo ML, Wei LH. IL-6 trans-signaling in formation and progression of malignant ascites in ovarian cancer. Cancer Res. 2011 Jan 15;71(2):424-34. (Impact Factor:8.234)
  21. Chen MW, Hua KT, Kao HJ, Chi CC, Wei LH, Johansson G, Shiah SG, Chen PS, Jeng YM, Cheng TY, Lai TC, Chang JS, Jan YH, Chien MH, Yang CJ, Huang MS, Hsiao M, Kuo ML*.H3K9 histone methyltransferase G9a promotes lung cancer invasion and metastasis by silencing the cell adhesion molecule Ep-CAM. Cancer Res. 2010 Oct 15;70(20):7830-40. (Impact Factor:8.234)
  22. Su JL, Chiou J, Tang CH, Zhao M, Tsai CH, Chen PS, Chang YW, Chien MH, Peng CY, Hsiao M, Kuo ML, Yen ML. CYR61 regulates BMP-2-dependent osteoblast differentiation through the {alpha}v{beta}3 integrin/integrin-linked kinase/ERK pathway. J Biol Chem. 2010 Oct 8;285(41):31325-36. (Impact Factor:5.328)
  23. Ueng TH, Chang YL, Tsai YY, Su JL, Chan PK, Shih JY, Lee YC, Ma YC, Kuo ML*. Potential roles of fibroblast growth factor-9 in the benzo(a)pyrene-induced invasion in vitro and the metastasis of human lung adenocarcinoma. Arch Toxicol. 2010 Aug;84(8):651-60. (Impact Factor:4.041)
  24. Cha ST, Chen PS, Johansson G, Chu CY, Wang MY, Jeng YM, Yu SL, Chen JS, Chang KJ, Jee SH, Tan CT, Lin MT, Kuo ML*. MicroRNA-519c suppresses hypoxia-inducible factor-1alpha expression and tumor angiogenesis. Cancer Res. 2010 Apr 1;70(7):2675-85. (Impact Factor:8.234)
  25. Chen YT, Furushima K, Hou PS, Ku AT, Deng JM, Jang CW, Fang H, Adams HP, Kuo ML, Ho HN, Chien CL, Behringer RR. PiggyBac transposon-mediated, reversible gene transfer in human embryonic stem cells. Stem Cells Dev. 2010 Jun;19(6):763-71. (Impact Factor:4.791)
  26. Chien MH, Ku CC, Johansson G, Chen MW, Hsiao M, Su JL, Inoue H, Hua KT, Wei LH, Kuo ML*. Vascular endothelial growth factor-C (VEGF-C) promotes angiogenesis by induction of COX-2 in leukemic cells via the VEGF-R3/JNK/AP-1 pathway. Carcinogenesis. 2009 Dec;30(12):2005-13. (Impact Factor:5.402)
  27. Hsu KW, Hsieh RH, Wu CW, Chi CW, Lee YH, Kuo ML, Wu KJ, Yeh TS. MBP-1 suppresses growth and metastasis of gastric cancer cells through COX-2. Mol Biol Cell. 2009 Dec;20(24):5127-37. (Impact Factor:5.861)
  28. Chen CH, Chien MH, Kuo ML, Chou CT, Lai JJ, Lin SF, Thummanagoti S, Sun CM. Diversity-oriented synthesis of angular bis-benzimidazole derivatives under microwave irradiation. J Comb Chem. 2009 Nov-Dec;11(6):1038-46. (Impact Factor:3.122)
  29. Yu CC, Hsu MJ, Kuo ML, Chen RF, Chen MC, Bai KJ, Yu MC, Chen BC, Lin CH. Thrombin-induced connective tissue growth factor expression in human lung fibroblasts requires the ASK1/JNK/AP-1 pathway. J Immunol. 2009 Jun 15;182(12):7916-27. (Impact Factor:5.745)
  30. Yeh TS, Wu CW, Hsu KW, Liao WJ, Yang MC, Li AF, Wang AM, Kuo ML, Chi CW. The activated Notch1 signal pathway is associated with gastric cancer progression through cyclooxygenase-2. Cancer Res. 2009 Jun 15;69(12):5039-48. (Impact Factor:8.234)
  31. Tjiu JW, Chen JS, Shun CT, Lin SJ, Liao YH, Chu CY, Tsai TF, Chiu HC, Dai YS, Inoue H, Yang PC, Kuo ML, Jee SH. Tumor-associated macrophage-induced invasion and angiogenesis of human basal cell carcinoma cells by cyclooxygenase-2 induction. J Invest Dermatol. 2009 Apr;129(4):1016-25. (Impact Factor:6.270)
  32. Wang MY, Chen PS, Prakash E, Hsu HC, Huang HY, Lin MT, Chang KJ, Kuo ML*. Connective tissue growth factor confers drug resistance in breast cancer through concomitant up-regulation of Bcl-xL and cIAP1. Cancer Res. 2009 Apr 15;69(8):3482-91. (Impact Factor:8.234)
  33. Chen CN, Chang CC, Su TE, Hsu WM, Jeng YM, Ho MC, Hsieh FJ, Lee PH, Kuo ML, Lee H, Chang KJ. Identification of calreticulin as a prognosis marker and angiogenic regulator in human gastric cancer. Ann Surg Oncol. 2009 Feb;16(2):524-33. (Impact Factor:4.182)
  34. Chu CY, Cha ST, Lin WC, Lu PH, Tan CT, Chang CC, Lin BR, Jee SH, Kuo ML*. Stromal cell-derived factor-1alpha (SDF-1alpha/CXCL12)-enhanced angiogenesis of human basal cell carcinoma cells involves ERK1/2-NF-kappaB/interleukin-6 pathway. Carcinogenesis. 2009 Feb;30(2):205-13. (Impact Factor:5.402)
  35. Gao M, Yeh PY, Lu YS, Hsu CH, Chen KF, Lee WC, Feng WC, Chen CS, Kuo ML, Cheng AL. OSU-03012, a novel celecoxib derivative, induces reactive oxygen species-related autophagy in hepatocellular carcinoma. Cancer Res. 2008 Nov 15;68(22):9348-57. (Impact Factor:8.234)
  36. Gao M, Yeh PY, Lu YS, Chang WC, Kuo ML, Cheng AL. NF-kappaB p50 promotes tumor cell invasion through negative regulation of invasion suppressor gene CRMP-1 in human lung adenocarcinoma cells. Biochem Biophys Res Commun. 2008 Nov 14;376(2):283-7. (Impact Factor:2.595)
  37. Chu CY, Chang CC, Prakash E, Kuo ML*. Connective tissue growth factor (CTGF) and cancer progression. J Biomed Sci. 2008 Nov;15(6):675-85. (Impact Factor:1.962)
  38. Shen CH, Chen HY, Lin MS, Li FY, Chang CC, Kuo ML, Settleman J, Chen RH. Breast tumor kinase phosphorylates p190RhoGAP to regulate rho and ras and promote breast carcinoma growth, migration, and invasion. Cancer Res. 2008 Oct 1;68(19):7779-87. (Impact Factor:8.234)
  39. Tan CT, Chu CY, Lu YC, Chang CC, Lin BR, Wu HH, Liu HL, Cha ST, Prakash E, Ko JY, Kuo ML*. CXCL12/CXCR4 promotes laryngeal and hypopharyngeal squamous cell carcinoma metastasis through MMP-13-dependent invasion via the ERK1/2/AP-1 pathway. Carcinogenesis. 2008 Aug;29(8):1519-27. (Impact Factor: 5.402)
  40. Cherng YG, Chang HC, Lin YL, Kuo ML, Chiu WT, Chen RM. Apoptotic insults to human chondrocytes induced by sodium nitroprusside are involved in sequential events, including cytoskeletal remodeling, phosphorylation of mitogen-activated protein kinase kinase kinase-1/c-Jun N-terminal kinase, and Bax-mitochondria- mediated caspase activation. J Orthop Res. 2008 Jul;26(7):1018-26. (Impact Factor:2.976)
  41. Su JL, Chen PS, Chien MH, Chen PB, Chen YH, Lai CC, Hung MC, Kuo ML*. Further evidence for expression and function of the VEGF-C/VEGFR-3 axis in cancer cells. Cancer Cell. 2008 Jun;13(6):557-60. (Impact Factor:26.925)
  42. Lin MT, Kuo IH, Chang CC, Chu CY, Chen HY, Lin BR, Sureshbabu M, Shih HJ, Kuo ML*. Involvement of hypoxia-inducing factor-1alpha-dependent plasminogen activator inhibitor-1 up-regulation in Cyr61/CCN1-induced gastric cancer cell invasion. J Biol Chem. 2008 Jun 6;283(23):15807-15. (Impact Factor: 5.328)
  43. Ho PY, Hsu SP, Liang YC, Kuo ML, Ho YS, Lee WS. Inhibition of the ERK phosphorylation plays a role in terbinafine-induced p21 up-regulation and DNA synthesis inhibition in human vascular endothelial cells. Toxicol Appl Pharmacol. 2008 May 15;229(1):86-93. (Impact Factor: 3.993)
  44. Lin BR, Chang CC, Chen LR, Wu MH, Wang MY, Kuo IH, Chu CY, Chang KJ, Lee PH, Chen WJ, Kuo ML, Lin MT. Cysteine-rich 61 (CCN1) enhances chemotactic migration, transendothelial cell migration, and intravasation by concomitantly up-regulating chemokine receptor 1 and 2. Mol Cancer Res. 2007 Nov;5(11):1111-23. (Impact Factor:8.234)
  45. Lin MT, Chang CC, Lin BR, Yang HY, Chu CY, Wu MH, Kuo ML*. Elevated expression of Cyr61 enhances peritoneal dissemination of gastric cancer cells through integrin alpha2beta1. J Biol Chem. 2007 Nov 23;282(47):34594-604. (Impact Factor: 5.328)
  46. Su JL, Yang CY, Zhao M, Kuo ML, Yen ML. Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. J Biol Chem. 2007 Jul 6;282(27):19385-98. (Impact Factor:5.328 )
  47. Chen PS, Wang MY, Wu SN, Su JL, Hong CC, Chuang SE, Chen MW, Hua KT, Wu YL, Cha ST, Babu MS, Chen CN, Lee PH, Chang KJ, Kuo ML*. CTGF enhances the motility of breast cancer cells via an integrin-alphavbeta3-ERK1/2- dependent S100A4-upregulated pathway. J Cell Sci. 2007 Jun 15;120(Pt 12):2053-65. (Impact Factor:6.290 )
  48. Lin MT, Lin BR, Chang CC, Chu CY, Su HJ, Chen ST, Jeng YM, Kuo ML*. IL-6 induces AGS gastric cancer cell invasion via activation of the c-Src/RhoA/ROCK signaling pathway. Int J Cancer.2007 Jun 15;120(12):2600-8. (Impact Factor:4.926 )
  49. Chu CY, Cha ST, Chang CC, Hsiao CH, Tan CT, Lu YC, Jee SH, Kuo ML*. Involvement of matrix metalloproteinase-13 in stromal-cell-derived factor 1 alpha-directed invasion of human basal cell carcinoma cells. Oncogene. 2007 Apr 12;26(17):2491-501.(Impact Factor:7.414 )
  50. Su JL, Yen CJ, Chen PS, Chuang SE, Hong CC, Kuo IH, Chen HY, Hung MC, Kuo ML*. The role of the VEGF-C/VEGFR-3 axis in cancer progression. Br J Cancer. 2007 Feb 26;96(4):541-5. (Impact Factor:4.831)