Professor Fuu-Jen Tsai

 
Specialty:
  1. Pediatrics
  2. Human Genetics
  3. Molecular Biology
 
Current Position:
  • Dean, Office of Research and Development, China Medical University
  • Director, Department of Medical Genetics, China Medical University Hospital
 
Education:
  • Ph.D., Institute of Chinese Medicine, China Medical College
  • M.S., Institute of Chinese Medicine, China Medical College
  • M.D., China Medical University, Taiwan
 
Tel: 04-22052121 #2041
Fax: 04-22033295
E-mail: d0704@mail.cmuh.org.tw
 
Introduction:
    Professor Fuu-Jen Tsai currently serves as Dean of Office of Research and Development, CMU, Professor of School of Chinese Medicine, Director of Department of Medical Genetics and Director of Genetic Center, CMU&H. Prof. Tsai's achievement in screening, diagnosis and treatment of rare diseases was awarded the National Award of Quality in Biotechnology and Medicine – Gold Medal in 2002 and Outstanding Achievement Award by Department of Health, Executive Yuan in 2004. Prof. Tsai's research in rare diseases, SNP and genetic diseases has made a significant contribution, publishing in Hepatology, PLoS Genet and Cancer Research.
 
Selected Publication:
  1. Wan L, Tsai CH, Hsu CM, Huang CC, Yang CC, Liao CC, Wu CC, Hsu YA, Lee CC, Liu SC, Lin WD, and Tsai FJ*. Mutation analysis and characterization of alternative splice variants of the Wilson disease gene ATP7B. Hepatology 2010;52:1662-70.
  2. Tsai FJ, Yang CF, Chen CC, Chuang LM, Lu CH, Chang CT, Wang TY, Chen RH, Shiu CF, Liu YM, Chang CC, Chen P, Chen CH, Fann CS, Chen YT, and Wu JY. A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese. PLoS Genet. 2010;6(2):e1000847.
  3. Liu YH, Chen RH, Chen WC, Tsai Y, Wan L, and Tsai FJ*. Disease association of the CD103 polymorphisms in Taiwan Chinese Graves' ophthalmopathy patients. Ophthalmology 2010;117(8):1645-51.
  4. Hsu WY, Lin WD, Hwu WL, Lai CC, and Tsai FJ*. Screening assay of very long chain Fatty acids in human plasma with multiwalled carbon nanotube-based surface-assisted laser desorption/ionization mass spectrometry. Anal Chem. 2010;82(16):6814-20.
  5. Lin YJ, Wan L, Wu JY, Sheu JJ, Lin CW, Lan YC, Lai CH, Hung CH, Tsai Y, Tsai CH, Lin TH, Lin JG, Hsueh KC, Huang YM, Chang JS, and Tsai FJ*. HLA-E gene polymorphism associated with susceptibility to Kawasaki disease and formation of coronary artery aneurysms. Arthritis Rheum. 2009 Feb;60(2):604-10.
 

    “Wilson disease” related publications

  1. Wan L, Tsai CH, Hsu CM, Huang CC, Yang CC, Liao CC, Wu CC, Hsu YA, Lee CC, Liu SC, Lin WD, and Tsai FJ*. Mutation analysis and characterization of alternative splice variants of the Wilson disease gene ATP7B. Hepatology 2010;52:1662-70.
  2. Lin CW, Er TK, Tsai FJ, Liu TC, Shin PY, and Chang JG. Development of a high-resolution melting method for the screening of Wilson disease-related ATP7B gene mutations. Clin Chim Acta 2010; 6; 411(17-18):1223-31.
  3. Wan L, Tsai CH, Tsai Y, Hsu CM, Lee CC, and Tsai FJ*. Mutation analysis of Taiwanese Wilson disease patients. Biochem Biophys Res Commun. 2006;30:345(2):734-8.

  4. “Type 2 diabetes” related publications

  5. Cho YS, Chen CH, Hu C, Long J, Ong RT, Sim X, Takeuchi F, Wu Y, Go MJ, Yamauchi T, Chang YC, Kwak SH, Ma RC, Yamamoto K, Adair LS, Aung T, Cai Q, Chang LC, Chen YT, Gao Y, Hu FB, Kim HL, Kim S, Kim YJ, Lee JJ, Lee NR, Li Y, Liu JJ, Lu W, Nakamura J, Nakashima E, Ng DP, Tay WT, Tsai FJ, Wong TY, Yokota M, Zheng W, Zhang R, Wang C, So WY, Ohnaka K, Ikegami H, Hara K, Cho YM, Cho NH, Chang TJ, Bao Y, Hedman K, Morris AP, McCarthy MI; DIAGRAM Consortium; MuTHER Consortium, Takayanagi R, Park KS, Jia W, Chuang LM, Chan JC, Maeda S, Kadowaki T, Lee JY, Wu JY, Teo YY, Tai ES, Shu XO, Mohlke KL, Kato N, Han BG, and Seielstad M. Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. Nat Genet. 2011 Dec 11;44(1):67-72. doi: 10.1038/ng.1019.
  6. Tsai FJ, Yang CF, Chen CC, Chuang LM, Lu CH, Chang CT, Wang TY, Chen RH, Shiu CF, Liu YM, Chang CC, Chen P, Chen CH, Fann CS, Chen YT, and Wu JY. A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese. PLoS Genet. 2010;6(2):e1000847.
  7. Lin HJ, Huang YC, Lin JM, Wu JY, Chen LA, Lin CJ, Tsui YP, Chen CP, and Tsai FJ*. Single-nucleotide polymorphisms in chromosome 3p14.1- 3p14.2 are associated with susceptibility of Type 2 diabetes with cataract. Mol Vis. 2010;16:1206-14.
  8. Huang YC, Lin JM, Lin HJ, Chen CC, Chen SY, Tsai CH, and Tsai FJ*. Genome-wide association study for diabetic retinopathy in a Taiwanese population. Ophthalmology 2010 (accept)
  9. Kuo WW, Chung LC, Liu CT, Wu SP, Kuo CH, Tsai FJ, Tsai CH, Lu MC, Huang CY, and Lee SD. Effects of insulin replacement on cardiac apoptotic and survival pathways in streptozotocin-induced diabetic rats. Cell Biochem Funct. 2009;27(7):479-87.
  10. Chen CC, Wu JY, Chang CT, Tsai FJ, Wang TY, Liu YM, Tsui HC, Chen RH, and Chiou SC. Levels of retinol-binding protein 4 and uric acid in patients with type 2 diabetes mellitus. Metabolism 2009; 58(12):1812-6.

  11. “Graves' disease”related publications

  12. Liao WL, Chen RH, Lin HJ, Liu YH, Chen WC, Tsai Y, Wan L, and Tsai FJ*. The Association between Polymorphisms of B7 Molecules (CD80 and CD86) and Graves' Ophthalmopathy in a Taiwanese Population. Ophthalmology 2010 Sep 28.
  13. Liu YH, Chen RH, Wu HH, Liao WL, Chen WC, Tsai Y, Tsai CH, Wan L, and  Tsai FJ*. Association of Interleukin-1 beta (IL1B) polymorphisms with Grave's Ophthalmopathy in Taiwan Chinese patients. Invest Ophthalmol Vis Sci. 2010 Jul 29.
  14. Liu YH, Chen RH, Chen WC, Tsai Y, Wan L, and Tsai FJ*. Disease association of the CD103 polymorphisms in Taiwan Chinese Graves' ophthalmopathy patients. Ophthalmology 2010;117(8):1645-51.
  15. Chen RH, Chang CT, Wang TY, Huang WL, Tsai CH, and Tsai FJ*. p53 codon 72 proline/arginine polymorphism and autoimmune thyroid diseases. J Clin Lab Anal. 2008;22(5):321-6.
  16. Chen RH, Chang CT, Wang TY, Chen CC, Tsai CH, and Tsai FJ*. Lack of association between interleukin-4 gene polymorphisms and autoimmune thyroid diseases amongst Taiwanese Chinese. Endocrine 2007;32(2):170-4.
  17. Chen RH, Chang CT, Chen HY, Chen WC, Tsai CH, and Tsai FJ*. Association between vitamin-D receptor gene FokI polymorphism and Graves' disease among Taiwanese Chinese. J Clin Lab Anal. 2007;21(3):173-7.
  18. Chen RH, Wang TY, Chen WC, Tsai CH, and Tsai FJ*. Association between the TAP2 gene codon 665 polymorphism and Graves' disease. J Clin Lab Anal. 2006;20(3):93-7.

  19. “Kawasaki disease” related publications

  20. Khor CC, Davila S, Breunis WB, Lee YC, Shimizu C, Wright VJ, Yeung RS, Tan DE, Sim KS, Wang JJ, Wong TY, Pang J, Mitchell P, Cimaz R, Dahdah N, Cheung YF, Huang GY, Yang W, Park IS, Lee JK, Wu JY, Levin M, Burns JC, Burgner D, Kuijpers TW, and Hibberd ML; Hong Kong–Shanghai Kawasaki Disease Genetics Consortium; Korean Kawasaki Disease Genetics Consortium; Taiwan Kawasaki Disease Genetics Consortium; International Kawasaki Disease Genetics Consortium; US Kawasaki Disease Genetics Consortium; Blue Mountains Eye Study.  Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease. Nat Genet. 2011 Nov 13;43(12):1241-6. doi: 10.1038/ng.981.
  21. Tsai FJ, Lee YC, Chang JS, Huang LM, Huang FY, Chiu NC, Chen MR, Chi H, Lee YJ, Chang LC, Liu YM, Wang HH, Chen CH, Chen YT, and Wu JY. Identification of novel susceptibility Loci for kawasaki disease in a Han chinese population by a genome-wide association study. PLoS One 2011; 4; 6(2):e16853.
  22. Hsieh YY, Lin YJ, Chang CC, Chen DY, Hsu CM, Lo MM, Hsu KH, and Tsai FJ*. Human lymphocyte antigen B-associated transcript 2, 3, and 5 polymorphisms and haplotypes are associated with susceptibility of Kawasaki disease and coronary artery aneurysm. J Clin Lab Anal. 2010;24(4):262-8.
  23. Huang YC, Lin YJ, Chang JS, Chen SY, Wan L, Sheu JJ, Lai CH, Lin CW, Liu SP, Chen CP, and Tsai FJ*. Single nucleotide polymorphism rs2229634 in the ITPR3 gene is associated with the risk of developing coronary artery aneurysm in children with Kawasaki disease. Int J Immunogenet. 2010;37(6):439-43.
  24. Sheu JJ, Lin YJ, Chang JS, Wan L, Chen SY, Huang YC, Chan C, Chiu IW, and Tsai FJ*. Association of COL11A2 polymorphism with susceptibility to Kawasaki disease and development of coronary artery lesions. Int J Immunogenet. 2010;37(6):487-92.
  25. Hsueh KC, Lin YJ, Chang JS, Wan L, and Tsai FJ*. BTNL2 gene polymorphisms may be associated with susceptibility to Kawasaki disease and formation of coronary artery lesions in Taiwanese children. Eur J Pediatr. 2010;169(6):713-9.
  26. Lin YJ, Wan L, Wu JY, Sheu JJ, Lin CW, Lan YC, Lai CH, Hung CH, Tsai Y, Tsai CH, Lin TH, Lin JG, Hsueh KC, Huang YM, Chang JS, and Tsai FJ*. HLA-E gene polymorphism associated with susceptibility to Kawasaki disease and formation of coronary artery aneurysms. Arthritis Rheum. 2009;60(2):604-10.
  27. Hsueh KC, Lin YJ, Chang JS, Wan L, Tsai YH, Tsai CH, Chen CP, and Tsai FJ*. Association of interleukin-10 A-592C polymorphism in Taiwanese children with Kawasaki disease. J Korean Med Sci. 2009;24(3):438-42.
  28. Chen SY, Wan L, Huang YC, Sheu JJ, Lan YC, Lai CH, Lin CW, Chang JS, Tsai Y, Liu SP, Lin YJ, and Tsai FJ*. Interleukin-18 gene 105A/C genetic polymorphism is associated with the susceptibility of Kawasaki disease. J Clin Lab Anal. 2009;23(2):71-6.
  29. Hsueh KC, Lin YJ, Chang JS, Wan L, Tsai YH, Tsai CH, and Tsai FJ*. Influence of interleukin 18 promoter polymorphisms in susceptibility to Kawasaki disease in Taiwan. J Rheumatol. 2008;35(7):1408-13.
  30. Hsueh KC, Lin YJ, Chang JS, Wan L, Tsai YH, Tsai CH, Chen CP, and Tsai FJ*. Association of vascular endothelial growth factor C-634 g polymorphism in taiwanese children with Kawasaki disease. Pediatr Cardiol. 2008;29(2):292-6.

  31. “Genetic biochemistry” related publications

  32. Hsu WY, Lin WD, Hwu WL, Lai CC, and Tsai FJ*. Screening assay of very long chain fatty acids in human plasma with multiwalled carbon nanotube-based surface-assisted laser desorption/ionization mass spectrometry. Anal Chem. 2010;82(16):6814-20.
  33. Jeng LB, Lo WY, Hsu WY, Lin WD, Lin CT, Lai CC, and Tsai FJ*. Analysis of urinary nucleosides as helper tumor markers in hepatocellular carcinoma diagnosis. Rapid Commun Mass Spectrom. 2009;23(11):1543-9.
  34. Lin WD, Wang CH, Lai CC, Tsai Y, Wu JY, Chen CP, and Tsai FJ*. Molecular analysis of Taiwanese patients with 3-hydroxy-3-methylglutaryl CoA lyase deficiency. Clin Chim Acta. 2009;401(1-2):33-6.
  35. Hsu WY, Lo WY, Lai CC, Tsai FJ*, Tsai CH, Tsai Y, Lin WD, and Chao MC. Rapid screening assay of trimethylaminuria in urine with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Rapid Commun Mass Spectrom. 2007;21(12):1915-9.
  36. Lin WD, Wang CH, Lee CC, Lai CC, Tsai Y, and Tsai FJ*. Genetic mutation profile of isovaleric acidemia patients in Taiwan. Mol Genet Metab. 2007;90(2):134-9.
* Corresponding author