Professor Chang-Fang Chiu

 
Specialty:
  1. Hematology
  2. Medical Oncology
  3. Cancer Biology
 
Current Position:
  • Vice Superintendent, Cancer Center, China Medical University Hospital
  • Professor, Department of Internal Medicine, China Medical University
 
Education:
  • Ph.D., Cornell University, New York, USA
  • M.D., Taipei Medical University, Taiwan
 
Tel: 04-22052121 #5054
Fax: 04-22337675
E-mail: d5686@mail.cmuh.org.tw
 
Introduction:
    Professor Chang-Fang Chiu is currently the Vice Superintendent of Cancer Center, CMUH. In the past decade, Prof. Chiu has had great contribution in the establishment of comprehensive program of hematopoietic stem cell transplantation, cancer center as well as clinical trial center at CMUH. In the recent 5 years, Prof. Chiu has been invited as Consultant and Reviewer of Center of Drug Evaluation, Food and Drug Administration (Taiwan) as well as Taiwan Cooperative Oncology Group (TCOG), NHRI, and a Surveyor of Good Clinical Practice (GCP) program. Prof. Chiu has also committed to the Cancer Care Quality Improving Projected funded by Department of Health, and is currently one of the few key persons in the establishment of Cancer Care Quality Accreditation Program of DOH. Prof. Chiu and his colleagues have published a number of articles in SCI journals, such as Cancer Research, Leukemia and Oral Oncology, etc. Dr. Chiu is also the co-PI of the prestigious multi-year program/flagship type grant, 'Center of Excellence for Cancer Research' funded by DOH and is an outstanding clinical scientist and leader.
 
Selected Publication:
  1. Bai LY, Ma Y, Kulp SK, Wang SH, Chiu CF, Frissora F, Mani R, Mo X, Jarjoura D, Byrd JC, Chen CS, Muthusamy N*. OSU-DY7, a novel D-tyrosinol derivative, mediates cytotoxicity in chronic lymphocytic leukemia and Burkitt lymphoma through p38 mitogen-activated protein kinase pathway. British Journal of Haematology 2011 (in press)
  2. Huang AC, Chang CL, Yu CS, Chen PY, Yang JS, Ji BC, Chiu CF, Yeh SP, Huang YP, Cherng LJ*, and Chung JG*. Induction of Apoptosis by Curcumin in Murine Myelomonocytic Leukemia WEHI-3 Cells is Mediated via Endoplasmic Reticulum Stress and Mitochondria-Dependent Pathways. Environmental Toxicology 2011 (in press)
  3. Bai LY, Omar HA, Chiu CF, Chi ZP, Hu JL, and Weng JR*. Antitumor eVects of (S)-HDAC42, a phenylbutyrate-derived histone deacetylase inhibitor, in multiple myeloma cells. Cancer Chemotherapy and Pharmacology 2011 (in press)
  4. Chang NW*, Tsai MH, Lin C, Hsu HT, Chu PY, Yeh CM, Chiu CF, and Yeh KT*. Fenofibrate exhibits a high potential to suppress the formation of squamous cell carcinoma in an oral-specific 4-nitroquinoline 1-oxide/arecoline mouse model. Biochimica et biophysica acta - Molecular basis of disease 2011 Apr;1812(4):558-64.
  5. Bau DT*, Chang CH, Tsai MH, Chiu CF, Tsou YA, Wang RF, Tsai CW, and Tsai RY*. Association Between DNA Repair Gene ATM Polymorphisms and Oral Cancer Susceptibility. Laryngoscopel 2010;120(12):2417-22.
  6. Wang HC, Liu CS, Wang CH, Tsai RY, Tsai CW, Wang RF, Chang CH, Chen YS, Chiu CF*, Bau DT*, and Huang CY*. Significant Association of XPD Asp312Asn Polymorphism with Breast Cancer in Taiwanese Patients. Chinese Journal of Physiology 2010 Mar;53(2):130-5.
  7. Chung LW, Hsieh CY, Chiu CF, and Bai LY*. Fludarabine-induced bradycardia in a patient with refractory leukemia. Annals of Saudi Medicine 2010 May;30(3):246-7.
  8. Ip SW, Lan SH, Huang AC, Yang JS, Chen YY, Huang HY, Lin ZP, Hsu YM, Yang MD, Chiu CF, and Chung JG*.Capsaicin induces apoptosis in SCC-4 human tongue cancer cells through mitochondria-dependent and -independent pathways. Environmental Toxicology 2010 (in press).
  9. Wu HC, Chang CH, Tsai RY, Lin CH, Wang RF, Tsai CW, Chen KB, Yao CH, Chiu CF, Bau DT*, Lin CC*. Significant association of methylenetetrahydrofolate reductase single nucleotide polymorphisms with prostate cancer susceptibility in Taiwan. Anticancer Research 2010 Sep;30(9):3573-8.
  10. Weng JR*, Bai LY, Omar HA, Sargeant AM, Yeh CT, Chen YY, Tsai MH, Chiu CF. A novel indole-3-carbinol derivative inhibits the growth of human oral squamous cell carcinoma in vitro. Oral Oncology 2010 Sep;46(1):748-54.
  11. Bai LY, Weng JR, Tsai CH, Sargeant A, Lin CW, and Chiu CF. OSU-03012 sensitizes TIB-196 myeloma cells to imatinib mesylate via AMP-acticated protein kinase and STAT3 pathways. Leukemia Research 2010;34:816-20. (corresponding)
  12. Lin WY, Chiu TY, Hsu HS, Davidson LE, Lin T, Cheng HC, Chiu CF, Li CY, Lin CC, and Liu CS. Medical expenditure and satisfaction of family between hospice care and general care in terminal cancer patient. J. The Formosan Med. Assoc. 2009;108(10):794-802.
  13. Wang HC, Chiu CF, Tsai RY, Kuo YS, Chen HS, Wang RF, Tsai CW, Chang CH, Lin CC, and Da-Tian Bau. Association of genetic polymorphisms of EXO1 gene with risk of breast cancer in Taiwan. Anticancer Research 2009;29(10):3897-902.
  14. Hsu CF, Tseng HC, Chiu CF, Liang SY, Tsai CW, Tsai MH, and Bau DT. Association between DNA double strand break gene Ku80 polymorphisms and oral susceptibility. Oral Oncology 2009;45(1):789-93
  15. Hsu NY, Wang HC, Wang CH, Chang CL, Chiu CF, Lee HZ, Tsai CW, and Bau DT. Lung cancer susceptibility and genetic polymorphism of DNA repair gene XRCC4 in Taiwan. Cancer Biomarkers: Section A of Disease Markers 2009;5(4):159-65.
  16. Tsai MH, Tseng HC, Liu CS, Chang CL, Tsai CW, Tsou YA, Wang RF, Lin CC, Wang HC, Chiu CF, and Bau DT*. Interaction of Exo1 genotypes and smoking habit in oral cancer in Taiwan. Oral Oncology 2009 Sep;45(9):e90-e94
  17. Chang CH, Chiu CF, Wang HC, Tsai RY, Tsai CW, Wang RF, Wang CH, Tsou YA, and Bau DT*. Significant Association of ERCC6 Single Nucleotide Polymorphisms with Bladder Cancer Susceptibility in Taiwan. Anticancer Research2009 Dec;29(12):5121-4
  18. Chang CH, Chang CL, Tsai CW, Wu HC, Chiu CF, Wang RF, Liu CS, Lin CC, and Bau DT. Significant association of an XRCC4 single nucleotide polymorphism with bladder cancer susceptibility in Taiwan. Anticancer Research 2009;29(5):1777-82.
  19. Chang CH, Chiu CF, Liang SY, Wu HC, Chang CL, Tsai CW, Wang HC, Lee HZ, and Bau DT. Significant association of Ku80 single nucleotide polymorphisms with bladder cancer susceptibility in Taiwan. Anticancer Research 2009;29(4):1275-9.
  20. Chiu CF, Tsai MH, Tseng HC, Wang CL, Wang CH, Wu CN, Lin CC, and Bau DT. A novel single nucleotide polymorphism in XRCC4 gene I associated with oral cancer susceptibility in Taiwanese patients. Oral Oncology 2008;44(9):898-902.
  21. Hsu NY, Wang HC, Wang CH, Chiu CF, Tseng HC, Liang SY, Tsai CW, Lin CC, and Bau DT. Lung cancer susceptibility and genetic polymorphisms of Exo 1 gene in Taiwan. Anticancer Research 2009;29(2)725-30.
  22. Hsieh CY, Bai LY, Lo WC, Huang HH, and Chiu CF. Esophageal squamous cell carcinoma with a solitary phalangeal metastasis. Southern Medical Journal 2008;101(11):1159-60.
  23. Hwang WS, Chao TY, Lin SF, Chung CY, Chiu CF, Chen YF, Chen PM, and Chiou TJ. Phase II study of oxaliplatin in combination with continuous infusion of 5-fluorouracil/leucovorin as first line chemotherapy in patients with advanced gastric cancer. Anti-Cancer Drugs 2008;19(3):283-8.
  24. Tseng HC, Tsai MH, Chiu CF, Wang CH, Chang NW, Huang CY, Tsai CW, Liang SY, Wang CL, and Bau DT. Association of XRCC4 codon 247 polymorphism with oral cancer susceptibility in Taiwan. Anticancer Research 2008;28(3A):1687-91.
  25. Chiu CF, Wang CH, Wang CL, Lin CC, Hsu NY, Weng JR, and Bau DT. A novel single nucleotide polymorphism in XRCC4 gene is associated with gastric cancer susceptibility in Taiwan. Annals of Surgical Oncology 2008;15(2):514-8.
  26. Chiu CF, Wang HC, Wang CL, Lin CC, Shen CY, Chiang SY and Bau DT. A New Single Nucleotide Polymorphism in XRCC4 Gene is Associated with Breast Cancer Susceptibility in Taiwanese Patients. Anticancer Research2008;28:267-70.
  27. Bai LY, Chiu CF, Lin CW, Hsu NY, Lin CL, Lo WJ, and Kao MC. Differential expression of Sonic hedgehog and Gli1 in hematological malignancies. Leukemia 2008, doi:10.1038/si.leu.2404978 (in press) (co-corresponding author)
  28. Wei-Shou, Chao TY, Lin SF, Chung CY, Chiu CF, Chang YF, Chen PM, and Chiou TJ. Phase II study of oxaliplatin in combination with continuous infusion of 5-fluorouracil/leucovorin as first line chemotherapy in patients with advanced gastric cancer. Anti-Cancer Drugs 2008;19(3):283-8.
  29. Chiu CF, Tsai MH, Tseng HC, Wang CL, Tsai FJ, Lin CC, and Bau DT. A Novel Single Nucleotide Polymorphism in ERCC6 Gene is Associated with Oral Cancer Susceptibility in Taiwanese Patients. Oral Oncol. 2008;44(6):582-6.
  30. Chang MC, Chen TY, Tang JL, Lan YJ, Chao TY, Chiu CF and Ho HT. Leukapheresis and cranial irradiation in patients with hyperleukocytic acute myeloid leukemia: No impact on early mortality and intracranial hemorrhage. Am J. Hematol. 2007;82(11):976-80.
  31. Weng JR, Tsai CH, Kulp SK, Wang D, Lin CH, Yang HC, Ma Y, Sargeant A, Chiu CF, Tsai MH, and Chen CS. A Potent Indole-3-Carbinol-Derived Antitumor Agent with Pleiotropic Effects on Multiple Signaling Pathways in Prostate Cancer Cells Cancer Research 2007;67(16):7815-24.
  32. Bai LY, Chiu CF, Liao YM, Yeh SP, Lin CY, and Huang HH. Recurrent lymphoma presenting as brachial plexus neuropathy. J Clin Oncol. 2007;25(6):726-8.